Yuanyuan Zeng, Xiaolan Yang, Shengda Tao, Ling Lei
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Two-sample MR analyses were performed separately for EA and the five CTDs.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>We found a negative causal relationship between EA and RA (OR<sub>IVW</sub> = 0.627, 95% CI = 0.537–0.732, <i>p</i> < .001), and SLE (OR<sub>IVW</sub> = 0.341, 95% CI = 0.123–0.944, <i>p</i> = .038). There were no genetic causal association between EA and SSc (OR<sub>IVW</sub> = 0.647, 95% CI = 0.351–1.195, <i>p</i> = .164), PM (OR<sub>IVW</sub> = 0.938, 95% CI = 0.320–2.746, <i>p</i> = .907), or DM (OR<sub>IVW</sub> = 0.754, 95% CI = 0.351–1.619, <i>p</i> = .468). None of the analyses revealed any horizontal pleiotropy or heterogeneity.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Our findings indicated a potential causal association between EA and RA, SLE, emphasizing the need for further investigation and potential integration of EA into clinical practice to enhance treatment strategies.</p>\n </section>\n </div>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"27 7","pages":""},"PeriodicalIF":4.6000,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of education attainment and risk of connective tissue diseases\",\"authors\":\"Yuanyuan Zeng, Xiaolan Yang, Shengda Tao, Ling Lei\",\"doi\":\"10.1111/1756-185X.15264\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>We employed two-sample Mendelian randomization (MR) to assess the genetic causal relationship between educational attainment (EA) and risk of five common connective tissue diseases (CTDs).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Educational attainment (self-reported at age ≥30 years) was obtained from a meta-analysis of years of schooling in 766 345 participants of European ancestry from genome-wide association studies (GWAS). A total of 1265 signals associated with EA were identified. Genetic data for five CTDs [rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), polymyositis (PM), and dermatomyositis (DM)] were obtained from the FinnGen consortium. Two-sample MR analyses were performed separately for EA and the five CTDs.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>We found a negative causal relationship between EA and RA (OR<sub>IVW</sub> = 0.627, 95% CI = 0.537–0.732, <i>p</i> < .001), and SLE (OR<sub>IVW</sub> = 0.341, 95% CI = 0.123–0.944, <i>p</i> = .038). There were no genetic causal association between EA and SSc (OR<sub>IVW</sub> = 0.647, 95% CI = 0.351–1.195, <i>p</i> = .164), PM (OR<sub>IVW</sub> = 0.938, 95% CI = 0.320–2.746, <i>p</i> = .907), or DM (OR<sub>IVW</sub> = 0.754, 95% CI = 0.351–1.619, <i>p</i> = .468). 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引用次数: 0
摘要
目的：我们采用双样本孟德尔随机法（MR）评估教育程度（EA）与五种常见结缔组织疾病（CTD）风险之间的遗传因果关系：我们采用双样本孟德尔随机法（MR）评估了受教育程度（EA）与五种常见结缔组织疾病（CTD）风险之间的遗传因果关系：教育程度（≥30 岁时的自我报告）是通过对全基因组关联研究（GWAS）中 766 345 名欧洲血统参与者的受教育年限进行荟萃分析获得的。共确定了 1265 个与 EA 相关的信号。五种 CTD [类风湿性关节炎（RA）、系统性红斑狼疮（SLE）、系统性硬化症（SSc）、多发性肌炎（PM）和皮肌炎（DM）]的基因数据来自芬兰基因联盟（FinnGen consortium）。对EA和五种CTD分别进行了双样本MR分析：我们发现 EA 与 RA 之间存在负因果关系（ORIVW = 0.627，95% CI = 0.537-0.732，p IVW = 0.341，95% CI = 0.123-0.944，p = .038）。EA与SSc（ORIVW = 0.647，95% CI = 0.351-1.195，p = .164）、PM（ORIVW = 0.938，95% CI = 0.320-2.746，p = .907）或DM（ORIVW = 0.754，95% CI = 0.351-1.619，p = .468）之间没有遗传因果关系。所有分析均未显示任何水平多向性或异质性：我们的研究结果表明，EA 与 RA 和系统性红斑狼疮之间存在潜在的因果关系，强调了进一步研究的必要性，以及将 EA 纳入临床实践以加强治疗策略的可能性。
Association of education attainment and risk of connective tissue diseases
Objective
We employed two-sample Mendelian randomization (MR) to assess the genetic causal relationship between educational attainment (EA) and risk of five common connective tissue diseases (CTDs).
Methods
Educational attainment (self-reported at age ≥30 years) was obtained from a meta-analysis of years of schooling in 766 345 participants of European ancestry from genome-wide association studies (GWAS). A total of 1265 signals associated with EA were identified. Genetic data for five CTDs [rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), polymyositis (PM), and dermatomyositis (DM)] were obtained from the FinnGen consortium. Two-sample MR analyses were performed separately for EA and the five CTDs.
Results
We found a negative causal relationship between EA and RA (ORIVW = 0.627, 95% CI = 0.537–0.732, p < .001), and SLE (ORIVW = 0.341, 95% CI = 0.123–0.944, p = .038). There were no genetic causal association between EA and SSc (ORIVW = 0.647, 95% CI = 0.351–1.195, p = .164), PM (ORIVW = 0.938, 95% CI = 0.320–2.746, p = .907), or DM (ORIVW = 0.754, 95% CI = 0.351–1.619, p = .468). None of the analyses revealed any horizontal pleiotropy or heterogeneity.
Conclusion
Our findings indicated a potential causal association between EA and RA, SLE, emphasizing the need for further investigation and potential integration of EA into clinical practice to enhance treatment strategies.
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