作为细菌和细胞之间桥梁的整合素:治疗伤口愈合的关键目标。

IF 6.3 1区 医学 Q1 DERMATOLOGY
Burns & Trauma Pub Date : 2024-07-16 eCollection Date: 2024-01-01 DOI:10.1093/burnst/tkae022
Dong Yu, Zhaoyu Lu, Yang Chong
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引用次数: 0

摘要

整合素是由α和β亚基组成的异二聚体,它们通过非共价相互作用结合在一起。整合素介导细胞外粘附分子与细胞内肌动蛋白细胞骨架之间的动态连接。整合素存在于各种组织和器官中,这些异二聚体在生物体的分子水平上参与各种生理和病理反应。伤口愈合是创伤性疾病恢复的关键过程,包括三个相互重叠的阶段:炎症、增殖和重塑。在整个伤口愈合过程中,整合素受到调控,以促进炎症、血管生成和再上皮化等过程。长时间的炎症可能导致伤口愈合失败,造成慢性伤口等情况。伤口中的细菌定植是造成慢性伤口的主要原因之一。整合素可促进细菌对宿主机体的感染作用,导致慢性炎症、细菌定植,最终导致伤口愈合失败。本研究调查了整合素在伤口愈合过程中作为细菌-细胞相互作用桥梁的作用,评估了整合素在慢性伤口形成过程中作为细菌抑制节点的作用,并讨论了将整合素作为伤口愈合治疗靶点所面临的挑战和前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Integrins as a bridge between bacteria and cells: key targets for therapeutic wound healing.

Integrins are heterodimers composed of α and β subunits that are bonded through non-covalent interactions. Integrins mediate the dynamic connection between extracellular adhesion molecules and the intracellular actin cytoskeleton. Integrins are present in various tissues and organs where these heterodimers participate in diverse physiological and pathological responses at the molecular level in living organisms. Wound healing is a crucial process in the recovery from traumatic diseases and comprises three overlapping phases: inflammation, proliferation and remodeling. Integrins are regulated during the entire wound healing process to enhance processes such as inflammation, angiogenesis and re-epithelialization. Prolonged inflammation may result in failure of wound healing, leading to conditions such as chronic wounds. Bacterial colonization of a wound is one of the primary causes of chronic wounds. Integrins facilitate the infectious effects of bacteria on the host organism, leading to chronic inflammation, bacterial colonization, and ultimately, the failure of wound healing. The present study investigated the role of integrins as bridges for bacteria-cell interactions during wound healing, evaluated the role of integrins as nodes for bacterial inhibition during chronic wound formation, and discussed the challenges and prospects of using integrins as therapeutic targets in wound healing.

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来源期刊
Burns & Trauma
Burns & Trauma 医学-皮肤病学
CiteScore
8.40
自引率
9.40%
发文量
186
审稿时长
6 weeks
期刊介绍: The first open access journal in the field of burns and trauma injury in the Asia-Pacific region, Burns & Trauma publishes the latest developments in basic, clinical and translational research in the field. With a special focus on prevention, clinical treatment and basic research, the journal welcomes submissions in various aspects of biomaterials, tissue engineering, stem cells, critical care, immunobiology, skin transplantation, and the prevention and regeneration of burns and trauma injuries. With an expert Editorial Board and a team of dedicated scientific editors, the journal enjoys a large readership and is supported by Southwest Hospital, which covers authors'' article processing charges.
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