Milena Bond, Alessandro Tomelleri, Maria A Reatini, Corrado Campochiaro, Giorgio Cattani, Lorenzo Dagna, Maurizio Rossini, Christian Dejaco, Giovanni Adami
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We used a Bayesian hierarchical model to determine patients' daily exposures to them. We employed conditional logistic regression to estimate the effect of exposure on GCA symptoms onset or ischemic complications.</p><p><strong>Results: </strong>We included 232 patients. A positive association was observed between exposure to PM<sub>10</sub> and GCA risk, with an incremental odd of 27.1% (95% confidence interval 5.8-52.6) for every 10-μg/m<sup>3</sup> increase in PM<sub>10</sub> concentration within a 60-day period. We did not find any significant association for shorter periods or with ischemic complications. Subgroup analysis found a significantly higher incremental risk at a 60-day lag for patients ≥70 years old. Comparing patients who were chronically exposed to high PM<sub>10</sub> levels (26.9 ± 13.8 μg/m<sup>3</sup>) to those who were not (11.9 ± 7.9 μg/m<sup>3</sup>) revealed that only in the former group was there an association between GCA onset and increased PM<sub>10</sub> levels in the preceding 60 days.</p><p><strong>Conclusion: </strong>Exposure to environmental PM<sub>10</sub> in the preceding 60 days seems to be associated with an increased risk of developing GCA, especially in older individuals with prolonged exposure to high levels of air pollution.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of Exposure to Environmental Particulate Matter on the Onset of Giant Cell Arteritis.\",\"authors\":\"Milena Bond, Alessandro Tomelleri, Maria A Reatini, Corrado Campochiaro, Giorgio Cattani, Lorenzo Dagna, Maurizio Rossini, Christian Dejaco, Giovanni Adami\",\"doi\":\"10.1002/acr.25404\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The aim of this study was to investigate the association between exposure to particulate matter with an aerodynamic diameter ≤10 μm (PM<sub>10</sub>) and the development of giant cell arteritis (GCA) and its ischemic complications.</p><p><strong>Methods: </strong>This was case-crossover study on consecutive patients who received a diagnosis of GCA in three hospitals in northern Italy between 2013 and 2021. 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引用次数: 0
摘要
研究目的本研究旨在探讨暴露于空气动力学直径≤10 μm(PM10)的颗粒物与巨细胞动脉炎(GCA)及其缺血性并发症之间的关系:这是一项病例交叉研究,研究对象是2013年至2021年期间在意大利北部三家医院接受GCA诊断的连续患者。PM10的小时和日平均浓度由意大利监测网络收集,并由Istituto Superiore per la Protezione e la Ricerca Ambientale存档,我们采用欧洲参考值进行测定。我们采用贝叶斯分层模型来确定患者每天接触这些物质的情况。我们采用条件逻辑回归法来估算暴露量对 GCA 症状发作或缺血性并发症的影响:我们纳入了 232 名患者。我们观察到 PM10 暴露与 GCA 风险之间存在正相关,60 天内 PM10 浓度每增加 10 微克/立方米,GCA 风险就会增加 27.1%(95% 置信区间为 5.8-52.6)。我们没有发现较短时间内或与缺血性并发症有任何明显关联。亚组分析发现,年龄≥70 岁的患者在 60 天滞后期的增量风险明显更高。将长期暴露于高PM10水平(26.9 ± 13.8 μg/m3)的患者与未暴露于高PM10水平(11.9 ± 7.9 μg/m3)的患者进行比较后发现,只有前一组患者的GCA发病与前60天内PM10水平升高有关:结论:前 60 天暴露于环境 PM10 似乎与 GCA 的发病风险增加有关,尤其是长期暴露于高浓度空气污染的老年人。
Impact of Exposure to Environmental Particulate Matter on the Onset of Giant Cell Arteritis.
Objective: The aim of this study was to investigate the association between exposure to particulate matter with an aerodynamic diameter ≤10 μm (PM10) and the development of giant cell arteritis (GCA) and its ischemic complications.
Methods: This was case-crossover study on consecutive patients who received a diagnosis of GCA in three hospitals in northern Italy between 2013 and 2021. The PM10 hourly and daily average concentrations, collected in the Italian monitoring network and archived by Istituto Superiore per la Protezione e la Ricerca Ambientale, were determined using European reference. We used a Bayesian hierarchical model to determine patients' daily exposures to them. We employed conditional logistic regression to estimate the effect of exposure on GCA symptoms onset or ischemic complications.
Results: We included 232 patients. A positive association was observed between exposure to PM10 and GCA risk, with an incremental odd of 27.1% (95% confidence interval 5.8-52.6) for every 10-μg/m3 increase in PM10 concentration within a 60-day period. We did not find any significant association for shorter periods or with ischemic complications. Subgroup analysis found a significantly higher incremental risk at a 60-day lag for patients ≥70 years old. Comparing patients who were chronically exposed to high PM10 levels (26.9 ± 13.8 μg/m3) to those who were not (11.9 ± 7.9 μg/m3) revealed that only in the former group was there an association between GCA onset and increased PM10 levels in the preceding 60 days.
Conclusion: Exposure to environmental PM10 in the preceding 60 days seems to be associated with an increased risk of developing GCA, especially in older individuals with prolonged exposure to high levels of air pollution.
期刊介绍:
Arthritis Care & Research, an official journal of the American College of Rheumatology and the Association of Rheumatology Health Professionals (a division of the College), is a peer-reviewed publication that publishes original research, review articles, and editorials that promote excellence in the clinical practice of rheumatology. Relevant to the care of individuals with rheumatic diseases, major topics are evidence-based practice studies, clinical problems, practice guidelines, educational, social, and public health issues, health economics, health care policy, and future trends in rheumatology practice.