圣布里德下教堂墓地(1770-1849 年,英国伦敦)中的一例可能患有低磷酸盐症的病例

IF 1.3 3区 地球科学 Q3 PALEONTOLOGY
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引用次数: 0

摘要

材料1770 年至 1849 年间埋葬在伦敦的一个未成年个体的骨骼遗骸。方法对遗骸进行了肉眼宏观检查,并辅以下颌骨和上颌骨的放射检查。对在这种考古背景下经常出现的可能情况进行了鉴别诊断。对牙齿病变进行了全面检查,以研究乳牙脱落的病因。结果该个体表现出一系列骨骼和牙齿病变,包括乳牙过早脱落、恒牙过早萌出、下颌骨和上颌骨普遍骨质流失、左桡骨骨髓炎、第二腰椎体溶骨性病变以及骨膜下新骨形成导致的肋骨轴明显膨胀。结论鉴别诊断表明,该患者的病理变化很可能与低磷酸盐血症和结核病的合并症有关。意义我们在这项研究中发现了一些口腔迹象,这些迹象可以提醒古病理学家和生物考古学家系统地考虑一种在考古环境中很少遇到的疾病的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A probable case of hypophosphatasia in St Bride’s Lower Churchyard (1770–1849, London, UK)

Objectives

The objective of this study was to analyse an individual whose remains are characterised by early deciduous tooth loss and multi-focal lesions on the post-cranial skeleton.

Materials

Skeletal remains of an immature individual buried between 1770 and 1849 in London.

Methods

The remains were examined by visual macroscopic inspection, supplemented by radiographic examination of the mandible and maxillae. A differential diagnosis with possible conditions, frequent in this archaeological context, was conducted. A comprehensive examination of dental lesions was performed to investigate the aetiologies of deciduous tooth loss.

Results

The individual exhibited a mosaic of skeletal and dental pathological changes, including premature loss of deciduous dentition, premature eruption of permanent teeth generalised bone loss in both the mandible and maxilla; osteomyelitis of the left radius; osteolytic lesion on the body of the second lumbar vertebra, and marked expansions of the rib shafts due to sub-periosteal new bone formation.

Conclusion

A differential diagnosis considered indicates that the pathological changes of the individual were most likely associated with a comorbidity involving hypophosphatasia and tuberculosis.

Significance

We present in this study several oral signs that could alert paleopathologists and bioarcheologists to systematically consider the potential of a condition that is rarely encountered in archaeological contexts.

Limitations

Due to poor preservation, this study was confined to the analysis of a partial maxilla and mandible, a left radius shaft and the axial skeleton (rib heads and vertebrae) of the individual.

Suggestions for further research

Further radiographic, histological and genetic analyses would confirm the diagnosis.

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来源期刊
CiteScore
2.90
自引率
25.00%
发文量
43
期刊介绍: Paleopathology is the study and application of methods and techniques for investigating diseases and related conditions from skeletal and soft tissue remains. The International Journal of Paleopathology (IJPP) will publish original and significant articles on human and animal (including hominids) disease, based upon the study of physical remains, including osseous, dental, and preserved soft tissues at a range of methodological levels, from direct observation to molecular, chemical, histological and radiographic analysis. Discussion of ways in which these methods can be applied to the reconstruction of health, disease and life histories in the past is central to the discipline, so the journal would also encourage papers covering interpretive and theoretical issues, and those that place the study of disease at the centre of a bioarchaeological or biocultural approach. Papers dealing with historical evidence relating to disease in the past (rather than history of medicine) will also be published. The journal will also accept significant studies that applied previously developed techniques to new materials, setting the research in the context of current debates on past human and animal health.
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