用于骨肿瘤治疗的 223Ra/99mTc 负载球形纳米羟基磷灰石的设计与体外评估

Nanomedicine (London, England) Pub Date : 2024-07-14 Epub Date: 2024-07-16 DOI:10.1080/17435889.2024.2365127

Yumei Wang, Yue Zhou, Dongliang Zhai, Hao Deng, Xiaoliang Chen

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引用次数: 0

摘要

目的：纳米羟基磷灰石（nHA）是负载 223Ra 的良好纳米载体，但 223Ra@nHA 的低比活度（sp.act.）限制了其在医学中的应用。方法：我们提出了一种以 PEG 为模板制备 nHA 的方法，该方法显著提高了 223Ra@nHA 的 sp.act.，并提出了一种负载 99mTc 用于体内追踪的新方法。结果：以 PEG 为模板合成的 nHA 与相同粒度、不含 PEG 的 nHA 相比，具有更高的 223Ra sp.act。负载 99mTc-MDP 的 nHA 与 99mTc 相比具有更高的标记率和稳定性。结论：所有这些发现都表明，使用 PEG 作为模板和 99mTc-MDP 合成 223Ra/99mTc@nHA 是最有效的方法。

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Design and in vitro evaluation of ²²³Ra/^99mTc-loaded spherical nano-hydroxyapatite in bone tumor therapy.

Aim: Nano-hydroxyapatite (nHA) is a good nanocarrier to load ²²³Ra, but the low specific activity (sp.act.) of ²²³Ra@nHA limits its application in medicine. Methods: We proposed a method for preparing nHA using PEG as a template, which significantly increases the sp.act of ²²³Ra@nHA and a new method to loaded ^99mTc for in vivo tracking. Results: The nHA synthesized using PEG as a template was associated with higher sp.act for ²²³Ra in comparison to nHA with identical particle size and without PEG. The nHA load ^99mTc-MDP was associated with higher labeling rate and stability in comparison to ^99mTc. Conclusion: All these findings suggest that using PEG as a template and ^99mTc-MDP could be the most effective of synthetic ²²³Ra/^99mTc@nHA.

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Nanomedicine (London, England)

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