在人体中测试新型抗惊厥药物所面临的生化挑战。

IF 3.3 3区 心理学 Q1 BEHAVIORAL SCIENCES
Kenneth B. Abrams, Isabel T. Folger, Nancy A. Cullen, Lawrence J. Wichlinski
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引用次数: 0

摘要

目前治疗惊恐障碍的药物都有很大的局限性,这表明我们需要新型抗焦虑药。药物开发成本高、成功率低,因此测试试验必须高效。人体实验室恐慌源挑战可快速生化诱导恐慌症状,因此是测试潜在抗恐慌药物的有效方法。本文描述了实验室致恐慌剂的理想特性,回顾了各种生化致恐慌剂的有效性和实用性,确定了新型抗恐慌药物研究的关键结果测量指标,并为希望开展此类研究的实验室提出了广泛的建议。最后,我们将恐慌源分为四个等级,将每种恐慌源与理想特征进行匹配,并反映出我们对实验室使用恐慌源的建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biochemical challenges for testing novel anti-panic drugs in humans

Current medications for panic disorder each carry significant limitations that indicate the need for novel anxiolytics. The high costs and low success rates of drug development demand that testing trials be efficient. Lab panicogenic challenges in humans allow for the rapid biochemical induction of panic symptoms and hence an efficient means of testing potential anti-panic drugs. This paper describes ideal characteristics of lab panicogens, reviews the validity and utility of various biochemical panicogenic agents, identifies key outcome measures for studies of novel anti-panic drugs, and makes broad recommendations for labs wishing to perform such studies. We conclude by presenting a four-tiered hierarchy of panicogens that matches each against ideal characteristics and reflects our recommendations for their laboratory use.

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来源期刊
CiteScore
6.40
自引率
2.80%
发文量
122
审稿时长
38 days
期刊介绍: Pharmacology Biochemistry & Behavior publishes original reports in the areas of pharmacology and biochemistry in which the primary emphasis and theoretical context are behavioral. Contributions may involve clinical, preclinical, or basic research. Purely biochemical or toxicology studies will not be published. Papers describing the behavioral effects of novel drugs in models of psychiatric, neurological and cognitive disorders, and central pain must include a positive control unless the paper is on a disease where such a drug is not available yet. Papers focusing on physiological processes (e.g., peripheral pain mechanisms, body temperature regulation, seizure activity) are not accepted as we would like to retain the focus of Pharmacology Biochemistry & Behavior on behavior and its interaction with the biochemistry and neurochemistry of the central nervous system. Papers describing the effects of plant materials are generally not considered, unless the active ingredients are studied, the extraction method is well described, the doses tested are known, and clear and definite experimental evidence on the mechanism of action of the active ingredients is provided.
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