Ryan Sandford, Ruchi Yadav, Emma K. Noble, Kelsey Sumner, Devyani Joshi, Sara Y. Tartof, Karen J. Wernli, Emily T. Martin, Manjusha Gaglani, Richard K. Zimmerman, H. Keipp Talbot, Carlos G. Grijalva, Edward A. Belongia, Christina Carlson, Melissa Coughlin, Brendan Flannery, Brad Pearce, Eric Rogier
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Antibody Response to Symptomatic Infection With SARS-CoV-2 Omicron Variant Viruses, December 2021–June 2022
We describe humoral immune responses in 105 ambulatory patients with laboratory-confirmed SARS-CoV-2 Omicron variant infection. In dried blood spot (DBS) collected within 5 days of illness onset and during convalescence, we measured binding antibody (bAb) against ancestral spike protein receptor binding domain (RBD) and nucleocapsid (N) protein using a commercial multiplex bead assay. Geometric mean bAb concentrations against RBD increased by a factor of 2.5 from 1258 to 3189 units/mL and by a factor of 47 against N protein from 5.5 to 259 units/mL between acute illness and convalescence; lower concentrations were associated with greater geometric mean ratios. Paired DBS specimens may be used to evaluate humoral response to SARS-CoV-2 infection.
期刊介绍：
Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases.
Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.
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