Bin Liu, Ying Peng, Yanjun Su, Chang Diao, Ruochuan Cheng
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引用次数: 0
摘要
目的：探讨甲状腺髓样微癌（MTMC）的个体化治疗和管理方法：探讨甲状腺髓样微癌（MTMC）的个体化治疗和管理方法：收集昆明医科大学第一附属医院2013年6月至20×年6月收治的直径≤1 cm甲状腺髓样癌患者的临床资料。结合甲状腺髓样癌的不同治疗指南，分析影响淋巴结转移的因素及术后疾病状态：结果：29例甲状腺髓样癌患者纳入分析，其中24例接受甲状腺全切除术，5例接受甲状腺腺叶切除术，13例术后出现淋巴结转移。多灶性肿瘤和降钙素（Ctn）是影响因素，而多灶性肿瘤、Ctn、淋巴结转移和AJCC分期则影响术后疾病的动态风险分层：结论：降钙素检测是发现MTMC的重要方法。结论：降钙素原检测是发现 MTMC 的重要方法，肿瘤直径≤1 cm 并不表示肿瘤处于早期。多灶性肿瘤和降钙素的存在应作为术前评估的重要指标。动态分层风险评估对术后随访至关重要。
Treatment and management of medullary thyroid microcarcinoma: a 10-year retrospective study from a single center.
Objective: To explore individualized treatment and management methods for medullary thyroid microcarcinoma (MTMC).
Methods: Clinical data of patients with medullary thyroid carcinoma with a diameter ≤1 cm admitted to the First Affiliated Hospital of Kunming Medical University from June 2013 to June 20× were collected. Combined with different treatment guidelines for medullary thyroid carcinoma, factors affecting lymph node metastasis and postoperative disease status were analyzed.
Results: Twenty-nine patients with MTMC were included in the analysis, including 24 patients who underwent total thyroidectomy, 5 who underwent thyroid gland lobectomy, and 13 who experienced postoperative lymph node metastasis. Multifocal tumor and calcitonin (Ctn) were the influencing factors, while multifocal tumor, Ctn, lymph node metastasis, and AJCC stage affected the dynamic risk stratification of postoperative disease.
Conclusion: Calcitonin detection is an important method for detecting MTMC. A tumor diameter ≤1 cm does not indicate that the tumor is in the early stage. The presence of multifocal tumors and Ctn should be used as important indicators for preoperative evaluation. Dynamic stratified risk assessment is critical in postoperative follow-up.
期刊介绍：
Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology.
Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted.
Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
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