有无肥胖症的脓毒症患者的甘油三酯血糖指数与短期死亡率之间的关系:一项回顾性队列研究。

IF 3.5 4区 生物学 Q2 ENDOCRINOLOGY & METABOLISM
Adipocyte Pub Date : 2024-12-01 Epub Date: 2024-07-16 DOI:10.1080/21623945.2024.2379867
Zhou Lv, Juntao Wang, Minglu Gu, Liuyan Zhou, Saie Shen, Chunmei Huang
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引用次数: 0

摘要

背景:脓毒症是导致重症监护病房(ICU)患者入院和死亡的一个重要因素,而肥胖的发病率却在不断上升。关于脓毒症患者,尤其是肥胖患者的 TyGI 与检查结果之间的相关性,目前还缺乏广泛的研究:本研究采用了回顾性队列设计,纳入了重症监护医学信息市场IV数据库中的脓毒症患者(≥18岁)。结果:8840名脓毒症患者(≥18岁)被纳入重症监护医学信息市场IV数据库:结果:8840 名脓毒症患者被纳入分析。重症监护室内的死亡率为 9.7%。非幸存者的TyGI水平明显高于幸存者[9.19(8.76-9.71) vs. 9.10(8.67-9.54), p p = 0.005]。限制性三次样条分析显示,在特定范围内,TyGI 与重症监护室内和院内死亡风险之间存在非线性关联。亚组分析显示,在全身肥胖、腹型肥胖和空腹血糖受损亚组中存在交互效应(p = 0.014、0.016 和 结论:TyGI与脓毒症相关的短期死亡风险和入住ICU后的不良结局增加有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between the triglyceride glucose index and short-term mortality in septic patients with or without obesity: a retrospective cohort study.

Background: Sepsis is a significant contributor to both intensive care unit (ICU) admissions and mortality among patients in ICU, with a rising prevalence of obesity. There is a lack of extensive research on the correlation between TyGI and findings in patients with sepsis, especially in obese patients.

Methods: This study used a retrospective cohort design and included patients with sepsis (≥18 years) from the Medical Information Mart for Intensive Care IV database. The association between TyGI and outcome was examined using multivariable logistic regression analysis.

Results: 8,840 patients with sepsis were included in the analysis. The in-ICU mortality rate was 9.7%. Non-survivors exhibited significantly greater TyGI levels than survivors [9.19(8.76-9.71) vs. 9.10(8.67-9.54), p < 0.001]. The adjusted multivariate regression model showed that elevated TyGI values were linked to a greater likelihood of death in ICU (odds ratio [OR] range 1.072-1.793, p < 0.001) and hospital (OR range 1.068-1.445, p = 0.005). Restricted Cubic Spline analysis revealed a nonlinear association between TyGI and in-ICU and in-hospital mortality risks within specified ranges. Subgroup analysis revealed interaction effects in the general obesity, abdominal obesity, and impaired fasting glucose subgroups (p = 0.014, 0.016, and < 0.001, respectively).

Conclusion: TyGI was associated with an increased sepsis-related short-term mortality risk and adverse outcomes after ICU admission.

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来源期刊
Adipocyte
Adipocyte Medicine-Histology
CiteScore
6.50
自引率
3.00%
发文量
46
审稿时长
32 weeks
期刊介绍: Adipocyte recognizes that the adipose tissue is the largest endocrine organ in the body, and explores the link between dysfunctional adipose tissue and the growing number of chronic diseases including diabetes, hypertension, cardiovascular disease and cancer. Historically, the primary function of the adipose tissue was limited to energy storage and thermoregulation. However, a plethora of research over the past 3 decades has recognized the dynamic role of the adipose tissue and its contribution to a variety of physiological processes including reproduction, angiogenesis, apoptosis, inflammation, blood pressure, coagulation, fibrinolysis, immunity and general metabolic homeostasis. The field of Adipose Tissue research has grown tremendously, and Adipocyte is the first international peer-reviewed journal of its kind providing a multi-disciplinary forum for research focusing exclusively on all aspects of adipose tissue physiology and pathophysiology. Adipocyte accepts high-profile submissions in basic, translational and clinical research.
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