Vioprolide B 及其脱氢丁炔甘氨酸类似物的合成与生物学评价

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2024-07-15 DOI:10.1039/D4CC02946A

Noé Osorio Reineke, Franziska A. V. Elsen, Hanusch A. Grab, Dietrich Mostert, Stephan A. Sieber and Thorsten Bach

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引用次数: 0

摘要

在本文中，我们介绍了全合成反肽类化合物 vioprolide B 及其类似物的方法，其中 (E)-dehydrobutyrine 氨基酸被甘氨酸取代。在生物试验中对这些化合物进行了研究，结果表明，vioprolide B 可能通过与延伸因子 eEF1A1 和染色质组装因子 CHAF1A 的半胱氨酸残基共价结合而具有细胞毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis and biological evaluation of vioprolide B and its dehydrobutyrine-glycine analogue†

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Synthesis and biological evaluation of vioprolide B and its dehydrobutyrine-glycine analogue†

Herein, we describe the total synthesis of the depsipeptide vioprolide B and of an analogue, in which the (E)-dehydrobutyrine amino acid was replaced by glycine. The compounds were studied in biological assays which revealed cytotoxicity solely for vioprolide B presumably by covalent binding to cysteine residues of elongation factor eEF1A1 and of chromatin assembly factor CHAF1A.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.