支链氨基酸及其下游代谢物在介导胰岛素抵抗中的作用。

IF 2.9 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Journal of Pharmacy and Pharmaceutical Sciences Pub Date : 2024-06-28 eCollection Date: 2024-01-01 DOI:10.3389/jpps.2024.13040
Abdualrahman Mohammed Abdualkader, Qutuba G Karwi, Gary D Lopaschuk, Rami Al Batran
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引用次数: 0

摘要

循环支链氨基酸(BCAAs)及其相关代谢物水平的升高与胰岛素抵抗和 2 型糖尿病密切相关。尽管进行了广泛的研究,但支链氨基酸水平升高与这些病症之间的确切关联机制仍然难以捉摸。在本综述中,我们将重点介绍参与维持 BCAA 平衡的关键器官,并讨论肥胖和胰岛素抵抗如何破坏这些器官之间错综复杂的相互作用,从而影响 BCAA 平衡。此外,我们概述了最近的研究,这些研究揭示了组织特异性或全身性 BCAA 代谢调节对循环 BCAA 水平、其代谢物和胰岛素敏感性的影响,同时还确定了具体的知识差距和需要进一步研究的领域。最后,我们总结了补充或限制 BCAA 对肥胖和胰岛素敏感性的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of branched-chain amino acids and their downstream metabolites in mediating insulin resistance.

Elevated levels of circulating branched-chain amino acids (BCAAs) and their associated metabolites have been strongly linked to insulin resistance and type 2 diabetes. Despite extensive research, the precise mechanisms linking increased BCAA levels with these conditions remain elusive. In this review, we highlight the key organs involved in maintaining BCAA homeostasis and discuss how obesity and insulin resistance disrupt the intricate interplay among these organs, thus affecting BCAA balance. Additionally, we outline recent research shedding light on the impact of tissue-specific or systemic modulation of BCAA metabolism on circulating BCAA levels, their metabolites, and insulin sensitivity, while also identifying specific knowledge gaps and areas requiring further investigation. Finally, we summarize the effects of BCAA supplementation or restriction on obesity and insulin sensitivity.

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来源期刊
CiteScore
6.90
自引率
0.00%
发文量
29
审稿时长
6-12 weeks
期刊介绍: The Journal of Pharmacy and Pharmaceutical Sciences (JPPS) is the official journal of the Canadian Society for Pharmaceutical Sciences. JPPS is a broad-spectrum, peer-reviewed, international pharmaceutical journal circulated electronically via the World Wide Web. Subscription to JPPS is free of charge. Articles will appear individually as soon as they are accepted and are ready for circulation.
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