国际自身免疫性肝炎病理学小组 2022 年建议与 2008 年自身免疫性肝炎简化标准的比较:初步研究。

IF 1.2 Q4 GASTROENTEROLOGY & HEPATOLOGY
Hepatology Forum Pub Date : 2024-07-02 eCollection Date: 2024-01-01 DOI:10.14744/hf.2023.2023.0061
Kenan Moral, Berkay Simsek, Veysel Baran Tomar, Cihad Albayrak, Mustafa Ergin, Guner Kilic, Ali Karatas, Nergiz Ekmen, Murat Kekilli, Mehmet Ibis, Tarkan Karakan, Mehmet Cindoruk, Guldal Esendagli, Gulen Akyol
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引用次数: 0

摘要

背景和目的:自身免疫性肝炎(AIH)的组织学诊断具有挑战性。国际自身免疫性肝炎病理学组提出了一项新的共识建议,以解决组织学诊断中的问题。本研究的目的是比较 2008 年的自身免疫性肝炎 "简化 "标准与 2022 年的 "共识建议 "在诊断灵敏度方面的差异:对 2010 年至 2022 年期间被诊断为自身免疫性肝炎(AIH)患者的病理标本进行了回顾性分析。在入选的 188 名患者中,根据排除标准选出了 88 名。标本由两名经验丰富的肝病病理学家和一名住院病理学家检查。所有标本均采用 "简化 "标准和新的共识建议进行分析:结果:在78名患者中,2022年共识建议将16名患者(20.5%)的诊断类别提升到了更高的级别。6名之前被诊断为 "非典型 "的患者现在被认为是 "可能的AIH",而10名诊断为 "符合 "的患者被提升为 "可能的AIH"。根据新的建议,没有发现患者属于较低的诊断类别。2008年标准与2022年共识报告在诊断灵敏度方面存在明显差异(p结论:与2008年 "简化 "组织学标准相比,2022年共识建议在诊断AIH方面可能更加敏感。要验证新共识建议的灵敏度和确定特异性,还需要进行更多的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of the recommendation of international autoimmune hepatitis pathology group 2022 and the simplified criteria for autoimmune hepatitis 2008: A preliminary study.

Background and aim: The histological diagnosis of autoimmune hepatitis (AIH) is challenging. A new consensus recommendation was provided by the International AIH Pathology Group to address the problems in the histological diagnosis. The purpose of this study is to compare the 2008 'simplified' criteria for AIH with the 'consensus recommendation' of 2022 in terms of diagnostic sensitivity.

Materials and methods: A retrospective analysis was conducted on pathological specimens of patients diagnosed with Autoimmune Hepatitis (AIH) between 2010 and 2022. Out of 188 patients enlisted, 88 were selected based on exclusion criteria. The specimens were examined by two experienced hepatopathologists and a resident pathologist. All specimens were analyzed using both the "simplified" criteria and the new consensus recommendations.

Results: Out of a total of 78 patients, the 2022 consensus recommendations raised the diagnostic category of 16 patients (20.5%) to a higher level. Six patients who were previously diagnosed as "atypical" were now considered "possible AIH", while 10 patients with a "compatible" diagnosis were elevated to "likely AIH" category. No patients were found to fall into a lower diagnostic category according to the new recommendations. A significant difference in diagnostic sensitivity was observed between the 2008 criteria and the 2022 consensus report (p<0.001).

Conclusion: The 2022 consensus recommendation may be more sensitive in the diagnosis of AIH in comparison to the 2008 'simplified' histological criteria. More studies are needed both for the validation of the sensitivity of the new consensus recommendation and for the determination of the specificity.

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