通过抑制钠转运体来阻止衰老

IF 12.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in molecular medicine Pub Date : 2024-11-01 Epub Date: 2024-07-14 DOI:10.1016/j.molmed.2024.07.002

Bettina Schock, Steven O'Reilly

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引用次数: 0

摘要

衰老与多种疾病相关，针对这些细胞的治疗是一个关键目标。在最近的一项研究中，Katsuumi 等人发现，靶向钠-葡萄糖协同转运体 2（SGLT2）可通过抑制程序性细胞死亡-1 配体（PD-L1）促进衰老细胞的免疫清除，从而促进免疫监视。这可能会对许多与年龄有关的疾病（包括癌症和虚弱）产生深远影响。

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Striking senescence with sodium transporter inhibition.

Senescence is associated with multiple morbidities and therapeutic targeting of these cells is a key aim. In a recent study, Katsuumi et al. found that targeting sodium-glucose co-transporter 2 (SGLT2) promoted immune clearance of senescent cells via programmed cell death-1 ligand (PD-L1) suppression, thus promoting immunosurveillance. This could have profound implications for many age-related diseases, including cancer and frailty.

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来源期刊

Trends in molecular medicine 医学-生化与分子生物学

CiteScore

24.60

自引率

0.00%

发文量

142

审稿时长

6-12 weeks

期刊介绍： Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.