双酚 a对男性生殖系统和男性后代的表观遗传效应。

IF 3.3 4区医学 Q2 REPRODUCTIVE BIOLOGY

Reproductive toxicology Pub Date : 2024-07-14 DOI:10.1016/j.reprotox.2024.108656

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引用次数: 0

摘要

双酚 A（BPA）是一种常用的有机化合物。在过去的几十年中，许多研究都对双酚 A 的毒性机制进行了探讨，其中双酚 A 诱导的表观遗传修饰改变受到了广泛关注。特别是在男性生殖系统中，表观遗传标记的异常改变会对生殖功能产生不利影响。此外，这些表观遗传标记的改变可通过父亲传给后代。在此，我们回顾了暴露于双酚 A 对男性生殖系统中各种表观遗传标记的影响，包括 DNA 甲基化、组蛋白修饰和非编码 RNA，以及男性生殖功能的相关变化。我们还回顾了父亲暴露于双酚 A 对后代表观遗传修饰模式的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bisphenol A: Epigenetic effects on the male reproductive system and male offspring

Bisphenol A (BPA) is a commonly used organic compound. Over the past decades, many studies have examined the mechanisms of BPA toxicity, with BPA-induced alterations in epigenetic modifications receiving considerable attention. Particularly in the male reproductive system, abnormal alterations in epigenetic markers can adversely affect reproductive function. Furthermore, these changes in epigenetic markers can be transmitted to offspring through the father. Here, we review the effects of BPA exposure on various epigenetic markers in the male reproductive system, including DNA methylation, histone modifications, and noncoding RNA, as well as associated changes in the male reproductive function. We also reviewed the effects of father's exposure to BPA on offspring epigenetic modification patterns.

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来源期刊

Reproductive toxicology 生物-毒理学

CiteScore

6.50

自引率

3.00%

发文量

131

审稿时长

45 days

期刊介绍： Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine. All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival. Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work. Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.