Ile-Pro-Pro 可减轻交感神经活动和高血压。

IF 3.7 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of physiology and biochemistry Pub Date : 2024-08-01 Epub Date: 2024-07-15 DOI:10.1007/s13105-024-01034-x
Jun-Liu Chen, Rui Ge, Xiu-Zhen Li, Yue Zhang, Wen-Yuan Hao, Na Li, Zhi-Qin Xu, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Xiao Tan
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引用次数: 0

摘要

异亮氨酸-脯氨酸-脯氨酸(Ile-Pro-Pro,IPP)是一种天然的食物来源三肽,可抑制血管紧张素转换酶(ACE)的活性。本研究旨在确定 IPP 在减轻交感神经活动、氧化应激和高血压方面的中枢和外周作用。雄性 Sprague-Dawley 大鼠接受了假手术(Sham)或双肾单夹(2K1C)手术,以诱发新血管性高血压。记录肾交感神经活动和血压。向下丘脑室旁核(PVN)双侧显微注射 IPP 可减轻交感神经活动(-16.1 ± 2.5%,P
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Ile-Pro-Pro attenuates sympathetic activity and hypertension.

Ile-Pro-Pro attenuates sympathetic activity and hypertension.

Isoleucine-proline-proline (Ile-Pro-Pro, IPP) is a natural food source tripeptide that inhibits angiotensin-converting enzyme (ACE) activity. The aim of this study was to determine the central and peripheral roles of IPP in attenuating sympathetic activity, oxidative stress and hypertension. Male Sprague-Dawley rats were subjected to sham-operated surgery (Sham) or two-kidney one-clip (2K1C) surgery to induce renovascular hypertension. Renal sympathetic nerve activity and blood pressure were recorded. Bilateral microinjections of IPP to hypothalamic paraventricular nucleus (PVN) attenuated sympathetic activity (-16.1 ± 2.5%, P < 0.001) and hypertension (-8.7 ± 1.5 mmHg, P < 0.01) in 2K1C rats by inhibiting ACE activity and subsequent angiotensin II and superoxide production in the PVN. Intravenous injections of IPP also attenuated sympathetic activity (-15.1 ± 2.1%, P < 0.001) and hypertension (-16.8 ± 2.3 mmHg, P < 0.001) via inhibiting ACE activity and oxidative stress in both PVN and arteries of 2K1C rats. The duration of the effects of the intravenous IPP was longer than those of the PVN microinjection, but the sympatho-inhibitory effect of intravenous injections occurred later than that of the PVN microinjection. Intraperitoneal injection of IPP (400 pmol/day for 20 days) attenuated hypertension and vascular remodeling via inhibiting ACE activity and oxidative stress in both PVN and arteries of 2K1C rats. These results indicate that IPP attenuates hypertension and sympathetic activity by inhibiting ACE activity and oxidative stress. The sympathoinhibitory effect of peripheral IPP is mainly caused by the ACE inhibition in PVN, and the antihypertensive effect is related to the sympathoinhibition and the arterial ACE inhibition. Long-term intraperitoneal IPP therapy attenuates hypertension, oxidative stress and vascular remodeling.

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来源期刊
Journal of physiology and biochemistry
Journal of physiology and biochemistry 生物-生化与分子生物学
CiteScore
6.60
自引率
0.00%
发文量
86
审稿时长
6-12 weeks
期刊介绍: The Journal of Physiology and Biochemistry publishes original research articles and reviews describing relevant new observations on molecular, biochemical and cellular mechanisms involved in human physiology. All areas of the physiology are covered. Special emphasis is placed on the integration of those levels in the whole-organism. The Journal of Physiology and Biochemistry also welcomes articles on molecular nutrition and metabolism studies, and works related to the genomic or proteomic bases of the physiological functions. Descriptive manuscripts about physiological/biochemical processes or clinical manuscripts will not be considered. The journal will not accept manuscripts testing effects of animal or plant extracts.
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