基于溶液的加压计量吸入器的动态喷雾羽流与药物沉积之间的相关性。

IF 2 4区 医学 Q3 RESPIRATORY SYSTEM
Yaru Zhou, Bo Yang, Chen Hong, Qi Shao, Ningyun Sun, Yibin Mao
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引用次数: 0

摘要

背景:由于缺乏可视化动态喷雾表征,因此很难了解雾化和药物颗粒形成的物理过程。本研究旨在调查溶液型加压计量吸入器(pMDIs)在不同条件下喷雾羽流形态和气动粒径的变化,以实现更好的药物沉积。方法:以溶液型 pMDIs 为研究对象,通过分析喷雾羽流和气动粒径的特征,研究推进剂浓度、喷嘴直径和雾化室容积等不同因素对药物沉积的影响。结果显示缩小致动器孔径和喷雾面积可使喷雾羽流集中,并延长持续时间和提高速度。此外,气动粒径 D50 和 D90 减小,而 D10 保持相对不变。减小致动器的雾化室容积会导致喷雾面积减小,持续时间延长,但羽流速度降低。D90 呈下降趋势,而 D10 和 D50 保持相对不变。降低处方中的推进剂浓度,喷雾面积和羽流速度先减小后增大。持续时间先增加后减少。D50 和 D90 的值呈先减后增的趋势,而 D10 则相对保持不变。结论:在开发过程中,应注意喷雾面积、喷雾角度、持续时间和喷雾羽流速度的变化。本研究建议分析喷雾羽流的特征,并结合两种或两种以上空气动力学粒度检测方法的数据,在体外验证沉积情况,以实现快速筛选,并在体内获得高肺部沉积。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlation Between Dynamic Spray Plume and Drug Deposition of Solution-Based Pressurized Metered-Dose Inhalers.

Background: The lack of visual dynamic spray characterization has made the understanding of the physical processes governing atomization and drug particle formation difficult. This study aimed to investigate the changes in the spray plume morphology and aerodynamic particle size of solution-based pressurized metered-dose inhalers (pMDIs) under different conditions to achieve better drug deposition. Methods: Solution-based pMDIs were studied, and the effects of various factors, such as propellant concentration, orifice diameters, and atomization chamber volume, on drug deposition were examined by analyzing the characteristics of spray plume and aerodynamic particle size. Results: Reducing the actuator orifice and spray area led to a concentrated spray plume and increased duration and speed. Moreover, the aerodynamic particle sizes D50 and D90 decreased, whereas D10 remained relatively unchanged. Decreasing the atomization chamber volume of the actuator led to reduced spray area and an increased duration but a decreased plume velocity. D90 exhibited a decreasing trend, whereas D10 and D50 remained relatively unchanged. Reducing the propellant concentration in the prescription, the spray area and the plume velocity first decreased and then increased. The duration initially increased and then decreased. The values of D50 and D90 showed an initial decreasing followed by an increasing trend, whereas D10 remained relatively unchanged. Conclusions: During the development process, attention should be paid to the changes in the spray area, spray angle, duration, and speed of the spray plume. This study recommended analyzing the characteristics of the spray plume and combining the data of two or more aerodynamic particle size detection methods to verify the deposition in vitro to achieve rapid screening and obtain high lung deposition in vivo.

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来源期刊
CiteScore
6.70
自引率
2.90%
发文量
34
审稿时长
>12 weeks
期刊介绍: Journal of Aerosol Medicine and Pulmonary Drug Delivery is the only peer-reviewed journal delivering innovative, authoritative coverage of the health effects of inhaled aerosols and delivery of drugs through the pulmonary system. The Journal is a forum for leading experts, addressing novel topics such as aerosolized chemotherapy, aerosolized vaccines, methods to determine toxicities, and delivery of aerosolized drugs in the intubated patient. Journal of Aerosol Medicine and Pulmonary Drug Delivery coverage includes: Pulmonary drug delivery Airway reactivity and asthma treatment Inhalation of particles and gases in the respiratory tract Toxic effects of inhaled agents Aerosols as tools for studying basic physiologic phenomena.
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