极低热量生酮饮食:对脂质代谢有何影响?

IF 4.6 3区 医学 Q1 NUTRITION & DIETETICS
Current Nutrition Reports Pub Date : 2024-09-01 Epub Date: 2024-07-15 DOI:10.1007/s13668-024-00556-6
Rosario Suarez, Sebastián Chapela, Natalia Daniela Llobera, Martha Montalván, Celina Andrade Vásquez, Andres Luciano Nicolas Martinuzzi, Christos S Katsanos, Ludovica Verde, Evelyn Frias-Toral, Luigi Barrea, Giovanna Muscogiuri
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引用次数: 0

摘要

综述目的:本综述旨在批判性地研究 VLCKD 如何影响血浆脂蛋白、脂质和胆固醇代谢。心血管疾病是影响数百万人的世界性健康问题,导致高死亡率和发病率。心血管疾病与循环胆固醇之间存在着公认的联系。目前有各种饮食建议用于治疗血脂异常:极低热量生酮饮食(VLCKD)作为包括血脂异常在内的几种病理状况的治疗方案正变得越来越流行。除了热量低以外,VLCKD 的主要特点是其独特的热量分配,强调减少碳水化合物的摄入,而以脂肪作为主要热量来源。通过 VLCKD 减少热量摄入可以减少胆固醇的内源性生成。但是,如果摄入的食物来自动物,由于动物产品的脂肪含量较高,膳食中胆固醇的摄入量可能会增加。这些饮食习惯结合在一起,可能会对血浆胆固醇水平产生相反的影响。有关 VLCKD 对血浆胆固醇和低密度脂蛋白胆固醇水平影响的研究报告结果相互矛盾。一些研究发现低密度脂蛋白胆固醇水平上升,而另一些研究则显示总胆固醇和低密度脂蛋白胆固醇下降,高密度脂蛋白胆固醇上升。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Very Low Calorie Ketogenic Diet: What Effects on Lipid Metabolism?

Purpose of review: This review aims to critically examine how VLCKD affects plasma lipoprotein, lipid and cholesterol metabolism. Cardiovascular disease is a worldwide health problem affecting millions of people and leading to high rates of mortality and morbidity. There is a well-established association between cardiovascular disease and circulating cholesterol. Various dietary recommendations are currently available for the management of dyslipidemia.

Recent findings: The very low-calorie ketogenic diet (VLCKD) is becoming increasingly popular as a treatment option for several pathological conditions, including dyslipidemia. In addition to being low in calories, the VLCKD's main feature is its unique calorie distribution, emphasizing a reduction in carbohydrate consumption in favor of fat as the primary calorie source. Lowering calorie intake through a VLCKD can reduce the endogenous production of cholesterol. However, if the foods consumed are from animal sources, dietary cholesterol intake may increase due to the higher fat content of animal products. When combined, these dietary practices may have opposing effects on plasma cholesterol levels. Studies investigating the impact of VLCKD on plasma cholesterol and low-density lipoprotein cholesterol levels report contradictory findings. While some studies found an increase in low-density lipoprotein cholesterol levels, others showed a decrease in total cholesterol and low-density lipoprotein cholesterol, along with an increase in high-density lipoprotein cholesterol.

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来源期刊
Current Nutrition Reports
Current Nutrition Reports Agricultural and Biological Sciences-Food Science
CiteScore
7.70
自引率
2.00%
发文量
59
期刊介绍: This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.
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