采用 Control-IQ 技术的 Tandem t:Slim X2 胰岛素泵对 1 型糖尿病儿童、青少年和青年患者的安全性和心理疗效:系统综述。

IF 3.8 3区 医学 Q2 Medicine
Diabetes Therapy Pub Date : 2024-10-01 Epub Date: 2024-07-15 DOI:10.1007/s13300-024-01618-2
Chiara Mameli, Giulia Marie Smylie, Marco Marigliano, Luca Zagaroli, Valentina Mancioppi, Claudio Maffeis, Vincenzo Salpietro, Gianvincenzo Zuccotti, Maurizio Delvecchio
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引用次数: 0

摘要

Tandem t:slim X2 胰岛素泵是采用 Control-IQ 技术的第二代胰岛素自动给药系统。它由一个 X2 胰岛素泵、一个集成的 Dexcom 传感器和一个嵌入式 "Control-IQ "算法组成,该算法可预测未来 30 分钟内的血糖水平,调整程序设定的基础胰岛素注射率,使血糖水平保持在 112.5 至 160 毫克/分升(8.9 毫摩尔/升)之间。当预测血糖水平升高超过 180 毫克/分升(10 毫摩尔/升)时,系统会自动提供胰岛素修正剂量。该系统已于 2016 年投入商业使用。我们回顾了目前有关该设备在儿童、青少年和年轻的 1 型糖尿病患者中的心理、安全性和运动相关结果的证据。我们筛选了 552 篇论文,但只有 21 篇手稿被纳入本综述。青少年糖尿病患者及其父母对低血糖的恐惧明显降低。有趣的是,与糖尿病有关的困扰也减少了;因此,该系统很受用户欢迎。糖尿病患者及其护理人员的睡眠质量也得到了一定程度的改善。尽管数据较少,但该系统与运动相关的低血糖发生率较低。最后,文献证据表明,该系统在改善个人心理状况方面是安全有效的。即使仍需采取进一步措施实现完全闭环,但这种第二代胰岛素自动输送系统减轻了糖尿病的负担。它能妥善解决 1 型糖尿病儿童、青少年和年轻成人的大多数心理问题,因此似乎已被广泛接受。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Safety and Psychological Outcomes of Tandem t:Slim X2 Insulin Pump with Control-IQ Technology in Children, Adolescents, and Young Adults with Type 1 Diabetes: A Systematic Review.

Safety and Psychological Outcomes of Tandem t:Slim X2 Insulin Pump with Control-IQ Technology in Children, Adolescents, and Young Adults with Type 1 Diabetes: A Systematic Review.

The Tandem t:slim X2 insulin pump is a second-generation automated insulin delivery system with Control-IQ technology. It consists of an X2 insulin pump, an integrated Dexcom sensor, and an embedded 'Control-IQ' algorithm, which predicts glucose levels 30 min in the future, adapting the programmed basal insulin rates to get glucose levels between 112.5 and 160 mg/dl (8.9 mmol/l). The system delivers automatic correction boluses of insulin when glucose levels are predicted to rise > 180 mg/dl (10 mmol/l). It has been commercially available since 2016. We reviewed the current evidence about the psychological, safety, and exercise-related outcomes of this device in children, adolescents, and young adults living with type 1 diabetes. We screened 552 papers, but only 21 manuscripts were included in this review. Fear of hypoglycemia is significantly reduced in young people with diabetes and their parents. Interestingly, diabetes-related distress is decreased; thus, the system is well accepted by the users. The sleeping quality of subjects living with diabetes and their caregivers is improved to a lesser extent as well. Despite the small number of data, this system is associated with a low rate of exercise-related hypoglycemia. Finally, evidence from the literature shows that this system is safe and effective in improving psychological personal outcomes. Even if further steps toward the fully closed loop are still mandatory, this second-generation automated insulin delivery system reduces the burden of diabetes. It properly addresses most psychological issues in children, adolescents, and young adults with type 1 diabetes mellitus; thus, it appears to be well accepted.

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来源期刊
Diabetes Therapy
Diabetes Therapy Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
6.90
自引率
7.90%
发文量
130
审稿时长
6 weeks
期刊介绍: Diabetes Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all areas of diabetes. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Diabetes Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.
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