超越简单的尾巴：多聚（A）尾介导的 RNA 表观遗传调控。

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2024-10-01 DOI:10.1016/j.tibs.2024.06.013

Jingwen Liu , Falong Lu

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引用次数: 0

摘要

多聚（A）尾是 mRNA 的重要结构成分，是后者稳定和翻译所必需的。最近的技术实现了对整个转录组的多聚（A）尾的长度和组成的分析，从而揭示了它们被忽视的调控能力。值得注意的是，聚（A）尾不仅含有腺嘌呤，还含有尿嘧啶、胞嘧啶和鸟嘌呤残基。这些发现有力地表明，多聚（A）尾可能编码丰富的调控信息，类似于已知的可逆 RNA 化学修饰。本综述旨在简明扼要地总结我们目前对 RNA 聚（A）尾的组成、动态和调控功能的了解。鉴于 RNA 多聚（A）尾能够携带遗传密码之外的丰富调控信息，我们提出了 "多聚（A）尾表观遗传信息 "的概念，作为 RNA 表观遗传调控的一个新层次。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Beyond simple tails: poly(A) tail-mediated RNA epigenetic regulation

The poly(A) tail is an essential structural component of mRNA required for the latter’s stability and translation. Recent technologies have enabled transcriptome-wide profiling of the length and composition of poly(A) tails, shedding light on their overlooked regulatory capacities. Notably, poly(A) tails contain not only adenine but also uracil, cytosine, and guanine residues. These findings strongly suggest that poly(A) tails could encode a wealth of regulatory information, similar to known reversible RNA chemical modifications. This review aims to succinctly summarize our current knowledge on the composition, dynamics, and regulatory functions of RNA poly(A) tails. Given their capacity to carry rich regulatory information beyond the genetic code, we propose the concept of ‘poly(A) tail epigenetic information’ as a new layer of RNA epigenetic regulation.

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.