利用 HANARO 对 166Ho 生产的热稳定性评估进行系统分析：一项硅学研究

IF 2.6 3区工程技术 Q1 NUCLEAR SCIENCE & TECHNOLOGY

Nuclear Engineering and Technology Pub Date : 2024-07-02 DOI:10.1016/j.net.2024.07.001

Taeyun Kim, Bo-Young Han, Seongwoo Yang, Jaegi Lee, Gwang-Min Sun, Byung-Gun Park, Sung-Joon Ye

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引用次数: 0

摘要

医用放射性同位素（RIs）被广泛用于肿瘤的诊断和治疗。Theranostic RIs，如 I、Ho、Lu 和 Re，因其能够同时进行诊断和治疗而特别引人注目。利用高通量先进中子应用反应堆（HANARO）（30 兆瓦的多用途研究反应堆）进行辐照试验，可以生产这些医用 RIs。在进行辐照试验之前，评估这些试验是否会影响辐照材料的热稳定性以及 HANARO 的热液压安全性至关重要。本研究系统地研究了利用 HANARO 的同位素生产辐照孔生产 Ho 的可行性，重点关注热稳定性。使用 MCNP6 计算了 RI 生产靶和 RI 胶囊的核加热率，并使用 COMSOL Multiphysics 对计算出的核加热率进行了三维传热分析。在本研究假定的条件下，Ho 生产不会影响 RI 生产靶和 RI 胶囊的热稳定性，因此可以满足 HANARO 的热-水力安全标准。本研究可为评估辐照材料的热稳定性和 HANARO 的热液压安全性提供有价值的参考。

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Systematic analysis for the thermal stability assessment of 166Ho production using HANARO: An in silico study

Medical radioisotopes (RIs) are widely used in the diagnosis and treatment of tumors. Theranostic RIs, such as I, Ho, Lu, and Re, are particularly notable for their ability to enable diagnosis and treatment simultaneously. Conducting irradiation tests using the High-flux Advanced Neutron Application Reactor (HANARO), a 30-MW multipurpose research reactor, enables the production of these medical RIs. Prior to irradiation tests, it is crucial to assess whether they affect the thermal stability of irradiated materials and the thermal-hydraulic safety of HANARO. This study systematically investigates the feasibility of Ho production using the isotope production irradiation hole of HANARO, focusing on thermal stability. The nuclear heating rates of the RI production target and RI capsule are calculated using MCNP6, and the calculated nuclear heating rates are used for three-dimensional heat transfer analysis using COMSOL Multiphysics. Under the assumed conditions in this study, Ho production did not compromise the thermal stability of the RI production target and RI capsule; consequently, the thermal-hydraulic safety criteria of HANARO could be satisfied. This study can serve as a valuable reference for evaluating the thermal stability of irradiated materials and the thermal-hydraulic safety of HANARO, which must be performed before irradiation tests using HANARO.

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来源期刊

Nuclear Engineering and Technology 工程技术-核科学技术

CiteScore

4.80

自引率

7.40%

发文量

431

审稿时长

3.5 months

期刊介绍： Nuclear Engineering and Technology (NET), an international journal of the Korean Nuclear Society (KNS), publishes peer-reviewed papers on original research, ideas and developments in all areas of the field of nuclear science and technology. NET bimonthly publishes original articles, reviews, and technical notes. The journal is listed in the Science Citation Index Expanded (SCIE) of Thomson Reuters. NET covers all fields for peaceful utilization of nuclear energy and radiation as follows: 1) Reactor Physics 2) Thermal Hydraulics 3) Nuclear Safety 4) Nuclear I&C 5) Nuclear Physics, Fusion, and Laser Technology 6) Nuclear Fuel Cycle and Radioactive Waste Management 7) Nuclear Fuel and Reactor Materials 8) Radiation Application 9) Radiation Protection 10) Nuclear Structural Analysis and Plant Management & Maintenance 11) Nuclear Policy, Economics, and Human Resource Development