亨廷顿症发病的主要因素亨廷廷蛋白。主要功能和细胞内蛋白质分解

IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY

Moscow University Chemistry Bulletin Pub Date : 2024-07-11 DOI:10.3103/S0027131424700160

N. N. Gotmanova, A. V. Bacheva

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引用次数: 0

摘要

摘要本综述专门探讨亨廷顿氏病特有的细胞内病理机制以及亨廷汀蛋白在这些过程中的核心作用。文章讨论了泛素-蛋白酶体系统和自噬作用利用突变亨廷顿蛋白聚集体的特点，以及蛋白酶体水解含多谷氨酰胺底物的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Huntingtin, the Major Factor in Huntington’s Disease Development. Main Functions and Intracellular Proteolysis

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Huntingtin, the Major Factor in Huntington’s Disease Development. Main Functions and Intracellular Proteolysis

This review is devoted to the consideration of pathological intracellular mechanisms characteristic of Huntington’s disease and the central role of huntingtin protein in these processes. The features of mutant huntingtin aggregates utilization by the ubiquitin–proteasome system and autophagy, as well as the possibilities of polyglutamine-containing substrates hydrolysis by proteasome are discussed.

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来源期刊

Moscow University Chemistry Bulletin CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.30

自引率

14.30%

发文量

期刊介绍： Moscow University Chemistry Bulletin is a journal that publishes review articles, original research articles, and short communications on various areas of basic and applied research in chemistry, including medical chemistry and pharmacology.