反应时间的个体内变异性(IIV)增加是多发性硬化症认知变化的最早指标:一项为期两年的观察研究

IF 5.3 1区 心理学 Q1 PSYCHOLOGY, CLINICAL
Giuseppina Pilloni , T. Charles Casper , Soe Mar , Jayne Ness , Teri Schreiner , Michael Waltz , Emmanuelle Waubant , Bianca Weinstock-Guttman , Yolanda Wheeler , Lauren Krupp , Leigh Charvet
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引用次数: 0

摘要

背景多发性硬化症(MS)患者的认知能力下降很常见,但无法预测,而且会随着病程的延长而加剧。因此,早期发现认知能力下降可提高干预措施的有效性。为此,符号数字模型测试(SDMT)可有效检测与认知功能障碍有关的处理速度缓慢,而在评估连续反应时间(RT)的试验中观察到的个体内变异性(IIV)可能是早期认知功能变化的有用指标。在此,我们将评估成人早期多发性硬化症患者的认知IIV变化。方法在全国范围内招募复发缓解型多发性硬化症(RRMS)患者,确诊时间为11年。基线和两年随访评估包括多发性硬化症简明国际认知评估(BICAMS)和Cogstate计算机测试。结果 66名参与者中共有44人完成了随访(平均年龄为34.0 ± 5.5岁;66%为女性;平均病程为4.1 ± 2.9年;中位残疾状况扩展量表(EDSS)评分为1.5 [0 - 6.0])。参与者按 SDMT z 评分中位数进行分组。各组在人口统计学或临床特征方面没有差异。基线SDMT较高的一组患者的RT速度较快(p = 0.05),变异性较小(IIV较低,p = 0.001)。结论 在早期多发性硬化症中,基线 SDMT 表现较高与认知变异性较低有关,但可能表明随着时间的推移,变异性容易增加,这突出了监测 IIV 早期认知变化的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Increased intraindividual variability (IIV) in reaction time is the earliest indicator of cognitive change in MS: A two-year observational study

Background

Cognitive decline in multiple sclerosis (MS) is common, but unpredictable, and increases with disease duration. As such, early detection of cognitive decline may improve the effectiveness of interventions. To that end, the Symbol Digit Modalities Test (SDMT) is effective in detecting slow processing speed as it relates to cognitive impairment, and intraindividual variability (IIV) observed in trials assessing continuous reaction time (RT) may be a useful indicator of early cognitive changes. Here, we will assess cognitive IIV changes in adults with early MS.

Methods

Adults with relapsing-remitting MS (RRMS), <11 years since diagnosis, were recruited nationally. Baseline and two-year follow-up assessments included Brief International Cognitive Assessment in MS (BICAMS) and Cogstate computerized tests. Intraindividual variability in RT was calculated from psychomotor tasks and data were age-normalized.

Results

A total of 44 of the 66 participants completed follow-up (mean age, 34.0 ± 5.5 years; 66 % female; mean disease duration, 4.1 ± 2.9 years; median Expanded Disability Status Scale (EDSS) score, 1.5 [0 to 6.0]). Participants were grouped by SDMT z-score median split. Groups did not differ in demographics or clinical features. The higher baseline SDMT group was faster (p = 0.05) in RT and less variable (lower IIV, p = 0.001). At the two-year follow-up, the higher SDMT group showed increased variability (p = 0.05) compared to the lower SDMT group, with no significant RT or BICAMS changes.

Conclusions

In early MS, higher SDMT performance at baseline is associated with less cognitive variability but may indicate susceptibility to increased variability over time, highlighting the importance of monitoring IIV for early cognitive changes.

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来源期刊
CiteScore
10.70
自引率
5.70%
发文量
38
审稿时长
33 days
期刊介绍: The International Journal of Clinical and Health Psychology is dedicated to publishing manuscripts with a strong emphasis on both basic and applied research, encompassing experimental, clinical, and theoretical contributions that advance the fields of Clinical and Health Psychology. With a focus on four core domains—clinical psychology and psychotherapy, psychopathology, health psychology, and clinical neurosciences—the IJCHP seeks to provide a comprehensive platform for scholarly discourse and innovation. The journal accepts Original Articles (empirical studies) and Review Articles. Manuscripts submitted to IJCHP should be original and not previously published or under consideration elsewhere. All signing authors must unanimously agree on the submitted version of the manuscript. By submitting their work, authors agree to transfer their copyrights to the Journal for the duration of the editorial process.
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