体重调整后的腰围指数是哮喘患者全因和特定原因死亡率的独立预测指标

IF 2.4 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Shidong Wang , Dai Li , Liping Sun
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引用次数: 0

摘要

背景肥胖与哮喘的发生有着密切的关系。体重调整腰围指数(WWI)是一种相对新颖的反映肥胖的人体测量参数。WWI = 腰围(厘米)/体重(千克)的平方根。根据受试者对标准化问卷的回答确定其是否患有哮喘。全因、心血管疾病 (CVD)、癌症和呼吸系统疾病死亡率信息是通过将这些数据与国家死亡指数进行前瞻性比对而获得的。研究采用了多变量调整后的考克斯比例危险回归分析、卡普兰-梅耶生存分析、限制性立方样条曲线(RCS)分析、分层分析和敏感性分析来阐明这些关联。在完全调整模型中,WWI 每增加一个单位与 43% (危险比 [HR] 和 95% 置信区间 [CI] = 1.43 [1.25,1.64], p < 0.0001)、58%(1.58 [1.25, 1.99],p <0.001)、50% (1.50 [1.19, 1.90],p <0.001)和 79% (1.79 [1.34, 2.39],p <0.0001)的全因死亡率、心血管疾病死亡率、癌症死亡率和呼吸系统疾病死亡率分别增加。RCS分析表明,一战与所有死亡风险之间基本呈线性关系。结论在成人哮喘人群中,WWI 是全因、心血管疾病、癌症和呼吸系统相关死亡率的独立预测因子。这些研究结果表明,WWI 作为一种简单易得的哮喘患者肥胖参数,可能具有新的预后价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Weight-adjusted waist index is an independent predictor of all-cause and cause-specific mortality in patients with asthma

Background

There is a close relationship between obesity and the occurrence of asthma.The weight-adjusted waist index (WWI) is a relatively novel anthropometric parameter that reflects obesity.

Objective

We aimed to explore the association between WWI and mortality in the asthma population.

Methods

We included adult with asthma from NHANES 1999–2018. WWI = Waist circumference (cm)/square root of body weight (kg). Current asthma was determined by the participant's responses in standardized questionnaires. All-cause, cardiovascular disease (CVD), cancer, and respiratory disease mortality information was obtained by prospectively matching these data to the National Death Index. Multivariate-adjusted Cox proportional hazards regression analyses, Kaplan Meier survival analyses, restricted cubic spline (RCS) analyses, stratified analyses, and sensitivity analyses were used to clarify these associations.

Results

A total of 101,316 participants were included in the study, and 3223 were diagnosed with asthma.WWI was independently and positively associated with all-cause and all factor-specific mortality in asthma. In fully adjusted models, each unit increase in WWI was associated with 43 % (hazard ratio [HR] and 95 % confidence interval [CI] = 1.43 [1.25,1.64], p < 0.0001), 58 % (1.58 [1.25, 1.99], p < 0.001), 50 % (1.50 [1.19, 1.90], p < 0.001), and 79 % (1.79 [1.34, 2.39], p < 0.0001) increased all-cause, CVD, cancer, and respiratory disease mortality, respectively. RCS analyses showed largely linear associations between WWI and all mortality risks. Stratified analyses indicated that these associations were influenced by multiple factors, and that age was consistently the effect modifier across all associations.

Conclusions

WWI is an independent predictor of all-cause, CVD, cancer, and respiratory-related mortality in the adult asthma population. These findings highlight that WWI may have novel prognostic value as a simple and easily accessible obesity parameter in asthma patients.

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来源期刊
Heart & Lung
Heart & Lung 医学-呼吸系统
CiteScore
4.60
自引率
3.60%
发文量
184
审稿时长
35 days
期刊介绍: Heart & Lung: The Journal of Cardiopulmonary and Acute Care, the official publication of The American Association of Heart Failure Nurses, presents original, peer-reviewed articles on techniques, advances, investigations, and observations related to the care of patients with acute and critical illness and patients with chronic cardiac or pulmonary disorders. The Journal''s acute care articles focus on the care of hospitalized patients, including those in the critical and acute care settings. Because most patients who are hospitalized in acute and critical care settings have chronic conditions, we are also interested in the chronically critically ill, the care of patients with chronic cardiopulmonary disorders, their rehabilitation, and disease prevention. The Journal''s heart failure articles focus on all aspects of the care of patients with this condition. Manuscripts that are relevant to populations across the human lifespan are welcome.
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