ALINA：未来为从不吸烟者进行 LDCT 肺癌筛查的又一块基石？

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2024-07-12 DOI:10.1016/j.medj.2024.05.010

Misako Nagasaka, Catherine T Ly, Sai-Hong Ignatius Ou

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引用次数: 0

摘要

ALINA 试验1 表明，在切除的早期（IB ≥ 4 厘米至 IIIA）ALK+ 非小细胞肺癌（NSCLC）患者中，与铂类双联化疗相比，阿来替尼辅助治疗 2 年可明显改善患者的 2 年总生存期和中枢神经系统（CNS）无病生存期。识别早期 ALK+ NSCLC 患者（ALINA 试验中 60% 的患者从不吸烟）可能需要对从不吸烟者进行低剂量计算机断层扫描（LDCT）肺癌筛查。

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ALINA: Another stepping stone toward a future of LDCT lung cancer screening in never-smokers?

The ALINA trial¹ demonstrated that 2 years of adjuvant alectinib achieved statistically significantly improved 2-year overall and central nervous system (CNS) disease-free survival over platinum-doublet chemotherapy in resected early-stage (IB ≥ 4 cm to IIIA) ALK+ non-small cell lung cancer (NSCLC). Identifying early-stage ALK+ NSCLC patients (60% were never-smokers in the ALINA trial) may require low-dose computed tomography (LDCT) lung cancer screening in never-smokers.

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

期刊介绍： Med is a flagship medical journal published monthly by Cell Press, the global publisher of trusted and authoritative science journals including Cell, Cancer Cell, and Cell Reports Medicine. Our mission is to advance clinical research and practice by providing a communication forum for the publication of clinical trial results, innovative observations from longitudinal cohorts, and pioneering discoveries about disease mechanisms. The journal also encourages thought-leadership discussions among biomedical researchers, physicians, and other health scientists and stakeholders. Our goal is to improve health worldwide sustainably and ethically. Med publishes rigorously vetted original research and cutting-edge review and perspective articles on critical health issues globally and regionally. Our research section covers clinical case reports, first-in-human studies, large-scale clinical trials, population-based studies, as well as translational research work with the potential to change the course of medical research and improve clinical practice.