坏死与自身免疫。

IF 4.5 3区 医学 Q2 IMMUNOLOGY
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引用次数: 0

摘要

自身免疫是一种正常的生理状态,需要免疫平衡和监控,而坏死则是一种炎症细胞死亡。当坏死发生时,各种免疫系统细胞必须履行相应的职责,以维护免疫平衡,无论其后果是扩大还是限制炎症反应,病理状态是被清除还是发展到自身免疫疾病阶段。本文讨论了在各种生理和病理情况下,以RIPK1-RIPK3-MLKL坏死体为调控核心,基于RIP同型相互作用基因(RHIM)相互作用的坏死。此外,还综述了参与自身免疫的坏死细胞生物学及其在自身免疫疾病中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Necroptosis and autoimmunity

Autoimmunity is a normal physiological state that requires immunological homeostasis and surveillance, whereas necroptosis is a type of inflammatory cell death. When necroptosis occurs, various immune system cells must perform their appropriate duties to preserve immunological homeostasis, whether the consequence is expanding or limiting the inflammatory response and the pathological condition is cleared or progresses to the autoimmune disease stage. This article discusses necroptosis based on RIP homotypic interaction motif (RHIM) interaction under various physiological and pathological situations, with the RIPK1-RIPK3-MLKL necrosome serving as the regulatory core. In addition, the cell biology of necroptosis involved in autoimmunity and its application in autoimmune diseases were also reviewed.

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来源期刊
Clinical immunology
Clinical immunology 医学-免疫学
CiteScore
12.30
自引率
1.20%
发文量
212
审稿时长
34 days
期刊介绍: Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.
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