光动力疗法在治疗癌症和微生物感染方面的双重作用。

IF 6.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2024-08-01 DOI:10.1016/j.drudis.2024.104099

Farheen Akhtar, Lama Misba, Asad U Khan

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引用次数: 0

摘要

光动力疗法（PDT）是一种微创疗法，在治疗癌症和微生物感染方面前景看好。光动力疗法以肿瘤细胞为目标，同时保护健康组织，减少副作用。它能诱导免疫性细胞死亡，可能刺激抗肿瘤免疫反应，减少癌症复发。在微生物治疗方面，PDT 能有效对抗细菌、真菌和病毒。将光动力疗法与化疗、放疗和免疫疗法结合使用可提高疗效。然而，由于存在肿瘤缺氧、有限的组织穿透力和光毒性等挑战，因此有必要不断开展研究，以优化光导光疗方案并克服其局限性。总之，光动力疗法用途广泛，并在不断改进完善方案，以提高其抗癌和抗微生物感染的临床实用性。

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The dual role of photodynamic therapy to treat cancer and microbial infection

Photodynamic therapy (PDT) is a minimally invasive treatment showing promise against cancer and microbial infections. PDT targets tumor cells while sparing healthy tissue, reducing side effects. It induces immunogenic cell death, potentially stimulating antitumor immune responses and reducing cancer recurrence. In microbial treatment, PDT effectively combats bacteria, fungi and viruses. Combining PDT with chemotherapy, radiotherapy and immunotherapy enhances its efficacy. However, challenges such as tumor hypoxia, limited tissue penetration and phototoxicity necessitate ongoing research efforts to optimize PDT protocols and overcome limitations. Overall, PDT is versatile and continually advancing with refined protocols to improve its clinical utility against cancer and microbial infections.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.