2 型糖尿病中的维生素 D 及其与热休克蛋白 70、血浆铁还原能力、高级氧化蛋白产物和高级糖化终产物的相关性。

IF 2.6 Q3 ENDOCRINOLOGY & METABOLISM

Endocrinology, Diabetes and Metabolism Pub Date : 2024-07-12 DOI:10.1002/edm2.508

Nazanin Hashemi, Sahar Karimpour Reyhan, Reihane Qahremani, Kiana Seifouri, Meraj Tavakoli, Seyed Arsalan Seyedi, Farahnaz Ghaemi, Mahsa Abbaszadeh, Alireza Esteghamati, Manouchehr Nakhjavani, Hossein Mirmiranpour, Soghra Rabizadeh

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引用次数: 0

摘要

目的：探讨维生素 D3 水平与 2 型糖尿病患者体内热休克蛋白 70（HSP70）、血浆铁还原能力（FRAP）、高级氧化蛋白产物（AOPP）和高级糖化终产物（AGEs）等氧化应激生物标志物之间的关系：在这项横断面研究中，纳入了从 2021 年至 2022 年在糖尿病门诊就诊的 54 名 T2D 患者，包括 32 名女性和 22 名男性，平均年龄为（54.92±11.37）岁。根据该人群维生素 D 的平均水平（14.91），将他们分为维生素 D ≤15 纳克/毫升和维生素 D >15 纳克/毫升两组。对维生素 D 与 AOPP、HSP 和 FRAP 参数之间的关系进行了多变量回归分析。通过皮尔逊相关检验评估了维生素 D 与其他变量之间的相关性：结果：维生素 D 水平与 FRAP（β = 0.32，p = 0.017）和 HSP（β = 0.39，p = 0.003）呈正相关，但与 AOPP 呈负相关（β = -0.30，p = 0.02）。2hPP 水平与维生素 D 水平也呈负相关（β = -0.33，p = 0.03）。维生素 D 水平与 AGEs 或其他变量之间没有任何关系。在多元回归模型中对多种混杂因素进行调整后，HSP 仍然显著：这项研究表明，2 型糖尿病患者的维生素 D 水平与氧化应激生物标志物之间存在关系。

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Vitamin D in Type 2 Diabetes and Its Correlation With Heat Shock Protein 70, Ferric Reducing Ability of Plasma, Advanced Oxidation Protein Products and Advanced Glycation End Products

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Vitamin D in Type 2 Diabetes and Its Correlation With Heat Shock Protein 70, Ferric Reducing Ability of Plasma, Advanced Oxidation Protein Products and Advanced Glycation End Products

Aim

To investigate the association between vitamin D3 level and oxidative stress biomarkers such as Heat Shock Protein 70 (HSP70), ferric reducing ability of plasma (FRAP), advanced oxidation protein products (AOPP) and advanced glycation end products (AGEs) in patients with Type 2 diabetes.

Method

In this cross-sectional study, 54 patients including 32 females and 22 males with a mean age of 54.92 ± 11.37 years with T2D attending the diabetes clinic from 2021 to 2022 were included. According to the average level of vitamin D in this population (14.91), they were divided into two groups with vitamin D ≤15 ng/mL and vitamin D >15 ng/mL. Multivariate regression analysis was conducted to evaluate the relationship between vitamin D and AOPP, HSP and FRAP parameters. The correlation between vitamin D and other variables was evaluated via the Pearson correlation test.

Result

Vitamin D level had a positive relation with FRAP (β = 0.32, p = 0.017) and HSP (β = 0.39, p = 0.003), but had a negative relation with AOPP (β = −0.30, p = 0.02). The level of 2hPP also had a negative relation with the level of vitamin D (β = −0.33, p = 0.03). There was not any relationship between the level of vitamin D and AGEs or other variables. After adjusting for multiple confounders for the multivariate regression model, HSP remained significant.