混乱的途径：辨析 SARS-CoV-2 感染中的细胞死亡机制

IF 17.6 1区医学 Q1 IMMUNOLOGY

Science Immunology Pub Date : 2024-07-12 DOI:10.1126/sciimmunol.adp8170

Lok-Yin Roy Wong, Stanley Perlman

引用次数: 0

摘要

感染 SARS-CoV-2 病毒后，受感染的细胞会发生坏死，而未受感染的旁观者细胞则会发生延迟凋亡和热凋亡，从而为无数未感染细胞的广泛损伤提供了合理的解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A confusion of pathways: Discerning cell death mechanisms in SARS-CoV-2 infection

Upon SARS-CoV-2 infection, infected cells undergo necroptosis, whereas delayed apoptosis and pyroptosis occur in uninfected, bystander cells, thus providing a plausible explanation for the extensive injury among myriad uninfected cells.

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来源期刊

Science Immunology Immunology and Microbiology-Immunology

CiteScore

32.90

自引率

2.00%

发文量

183

期刊介绍： Science Immunology is a peer-reviewed journal that publishes original research articles in the field of immunology. The journal encourages the submission of research findings from all areas of immunology, including studies on innate and adaptive immunity, immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology. Additionally, the journal covers research on immune contributions to health and disease, such as host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency. Science Immunology maintains the same high-quality standard as other journals in the Science family and aims to facilitate understanding of the immune system by showcasing innovative advances in immunology research from all organisms and model systems, including humans.