类黄酮对神经可塑性的多方面影响。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Veronica Rivi, Anuradha Batabyal, Ken Lukowiak
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引用次数: 0

摘要

随着人类寿命的延长,多种神经退行性疾病和绝症的发病率也在大幅上升。这凸显了人们迫切需要更全面地了解生活方式的不同方面,尤其是饮食,会如何影响神经功能,进而影响认知能力,以及如何增强整体健康。在各种水果、蔬菜和衍生饮料中发现的类黄酮提供了一个新的研究途径,显示出对大脑功能不同方面的良好影响。然而,尽管证据确凿,但大多数生物活性化合物缺乏强有力的临床研究功效。在本综述中,我们重点介绍了黄酮类化合物对脊椎动物和无脊椎动物的认知能力和神经可塑性的影响,并特别强调了对池塘蜗牛(Lymnaea stagnalis)的研究。最后,我们提出了未来的研究方向,并讨论了生物活性化合物的社会、文化和种族依赖性,这些因素影响着这些化合物在全球范围内的使用和接受程度。弥合生物活性天然化合物对大脑健康影响的临床前研究与临床研究之间的差距,必将带来生活方式的选择,如膳食黄酮类化合物的补充使用,而不是传统药物的替代品,从而带来更健康的未来。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The multifaceted effects of flavonoids on neuroplasticity.

There has been a significant increase in the incidence of multiple neurodegenerative and terminal diseases in the human population with life expectancy increasing in the current times. This highlights the urgent need for a more comprehensive understanding of how different aspects of lifestyle, in particular diet, may affect neural functioning and consequently cognitive performance as well as in enhancing overall health. Flavonoids, found in a variety of fruits, vegetables, and derived beverages, provide a new avenue of research that shows a promising influence on different aspects of brain function. However, despite the promising evidence, most bioactive compounds lack strong clinical research efficacy. In the current scoping review, we highlight the effects of Flavonoids on cognition and neural plasticity across vertebrates and invertebrates with special emphasis on the studies conducted in the pond snail, Lymnaea stagnalis, which has emerged to be a functionally dynamic model for studies on learning and memory. In conclusion, we suggest future research directions and discuss the social, cultural, and ethnic dependencies of bioactive compounds that influence how these compounds are used and accepted globally. Bridging the gap between preclinical and clinical studies about the effects of bioactive natural compounds on brain health will surely lead to lifestyle choices such as dietary Flavonoids being used complementarily rather than as replacements to classical drugs bringing about a healthier future.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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