具有铁中毒诱导活性的 Tithonia diversifolia 中的倍半萜内酯。

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2024-07-10 DOI:10.1016/j.phytochem.2024.114219

Ao-Xue Ding , Yi-Ming Shan , Chen-Yue Li , Guo-Qing Qin , Tong Chen , Qing Wang , Xiang-Gang Hu , Peng-Ju Guo , Hai-Jun Yu , Wen-Qiong Wang , Li-Jiang Xuan

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引用次数: 0

摘要

从 Tithonia diversifolia (Hemsl.) A. Gray 的气生部分分离出了 8 个以前未曾描述过的倍半萜内酯（1-8）和 6 个已知的倍半萜内酯（9-14）。利用 HRMS、NMR 光谱、旋光测量、X 射线晶体学和 ECD 等方法阐明了这些化合物的绝对构型。其中，倍半萜内酯 2-4 具有独特的碳骨架，具有罕见的 C-3/C-4 开环结构。化合物 1 和 8 通过促进脂质 ROS 的产生，对 CT26 小鼠结肠癌细胞表现出适度的抑制作用，突出了它们作为铁变态反应诱导剂的潜力。

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Sesquiterpene lactones from Tithonia diversifolia with ferroptosis-inducing activities

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Sesquiterpene lactones from Tithonia diversifolia with ferroptosis-inducing activities

Eight previously undescribed sesquiterpene lactones (1–8), together with six known ones (9–14) were isolated from the aerial parts of Tithonia diversifolia (Hemsl.) A. Gray. The absolute configurations of these compounds were elucidated using HRMS, NMR spectroscopy, optical rotation measurements, X-ray crystallography, and ECD. Among them, sesquiterpene lactones 2–4 share a unique carbon skeleton with a rare C-3/C-4 ring-opened structure. Compounds 1 and 8 showed moderate inhibitory effects toward CT26 murine colon carcinoma cells by promoting lipid ROS production, highlighting their potential as ferroptosis inducers.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.