S Alexander Ammerman, Alexander Keister, Joshua Vignolles-Jeong, Noah Mallory, David C Gibbs, Ryan G Eaton, Jianing Ma, David S Xu, Stephanus Viljoen, Andrew J Grossbach
{"title":"阿片类药物流行期间脊椎骨髓炎/椎间盘炎的微生物病因。","authors":"S Alexander Ammerman, Alexander Keister, Joshua Vignolles-Jeong, Noah Mallory, David C Gibbs, Ryan G Eaton, Jianing Ma, David S Xu, Stephanus Viljoen, Andrew J Grossbach","doi":"10.3171/2024.4.SPINE231071","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The primary goal of this study was to establish the current microbial trends in vertebral osteomyelitis/discitis (VOD) amid the opioid epidemic and to determine if intravenous drug use (IVDU) predisposes one to a unique microbial profile of infection.</p><p><strong>Methods: </strong>The authors performed a retrospective cohort study consisting of 1175 adult patients diagnosed with VOD between 2011 and 2022 at a single quaternary center. Data were acquired through retrospective chart review, with pertinent demographic and clinical information collected.</p><p><strong>Results: </strong>Staphylococcus aureus was the most cultured organism in both the IVDU and non-IVDU groups at 56.1% and 40.7%, respectively. In the IVDU cohort, Serratia marcescens was the next most prevalently cultured organism at 13.9%.</p><p><strong>Conclusions: </strong>The present study demonstrates that in the IVDU population S. marcescens is an organism of high concern. The potential for Serratia spp. infection should be accounted for when selecting empirical antimicrobial therapy in VOD patients.</p>","PeriodicalId":16562,"journal":{"name":"Journal of neurosurgery. Spine","volume":" ","pages":"551-558"},"PeriodicalIF":2.9000,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Microbial etiology of vertebral osteomyelitis/discitis amid the opioid epidemic.\",\"authors\":\"S Alexander Ammerman, Alexander Keister, Joshua Vignolles-Jeong, Noah Mallory, David C Gibbs, Ryan G Eaton, Jianing Ma, David S Xu, Stephanus Viljoen, Andrew J Grossbach\",\"doi\":\"10.3171/2024.4.SPINE231071\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The primary goal of this study was to establish the current microbial trends in vertebral osteomyelitis/discitis (VOD) amid the opioid epidemic and to determine if intravenous drug use (IVDU) predisposes one to a unique microbial profile of infection.</p><p><strong>Methods: </strong>The authors performed a retrospective cohort study consisting of 1175 adult patients diagnosed with VOD between 2011 and 2022 at a single quaternary center. Data were acquired through retrospective chart review, with pertinent demographic and clinical information collected.</p><p><strong>Results: </strong>Staphylococcus aureus was the most cultured organism in both the IVDU and non-IVDU groups at 56.1% and 40.7%, respectively. In the IVDU cohort, Serratia marcescens was the next most prevalently cultured organism at 13.9%.</p><p><strong>Conclusions: </strong>The present study demonstrates that in the IVDU population S. marcescens is an organism of high concern. The potential for Serratia spp. infection should be accounted for when selecting empirical antimicrobial therapy in VOD patients.</p>\",\"PeriodicalId\":16562,\"journal\":{\"name\":\"Journal of neurosurgery. Spine\",\"volume\":\" \",\"pages\":\"551-558\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-07-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of neurosurgery. Spine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3171/2024.4.SPINE231071\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/10/1 0:00:00\",\"PubModel\":\"Print\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of neurosurgery. Spine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3171/2024.4.SPINE231071","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/1 0:00:00","PubModel":"Print","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Microbial etiology of vertebral osteomyelitis/discitis amid the opioid epidemic.
Objective: The primary goal of this study was to establish the current microbial trends in vertebral osteomyelitis/discitis (VOD) amid the opioid epidemic and to determine if intravenous drug use (IVDU) predisposes one to a unique microbial profile of infection.
Methods: The authors performed a retrospective cohort study consisting of 1175 adult patients diagnosed with VOD between 2011 and 2022 at a single quaternary center. Data were acquired through retrospective chart review, with pertinent demographic and clinical information collected.
Results: Staphylococcus aureus was the most cultured organism in both the IVDU and non-IVDU groups at 56.1% and 40.7%, respectively. In the IVDU cohort, Serratia marcescens was the next most prevalently cultured organism at 13.9%.
Conclusions: The present study demonstrates that in the IVDU population S. marcescens is an organism of high concern. The potential for Serratia spp. infection should be accounted for when selecting empirical antimicrobial therapy in VOD patients.
期刊介绍：
Primarily publish original works in neurosurgery but also include studies in clinical neurophysiology, organic neurology, ophthalmology, radiology, pathology, and molecular biology.
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