拉丁美洲老龄化和痴呆症的环境-遗传相互作用

IF 28.2 1区医学 Q1 CLINICAL NEUROLOGY

Nature Reviews Neurology Pub Date : 2024-07-12 DOI:10.1038/s41582-024-00998-0

Agustin Ibanez, Andrea Slachevsky

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引用次数: 0

摘要

目前的痴呆症研究已经开发出环境与遗传相互作用的复杂模型，以更好地处理多模式疾病表型。新的证据强调，与拉丁美洲和加勒比地区特有的祖先效应相比，社会健康决定因素的影响更大，这为解决这些相互作用在老龄化和痴呆症中的多样性问题开辟了新的议程。一项关于拉丁美洲痴呆症发病率的新研究发现，与该地区特有的血统效应相比，社会健康决定因素的影响更大，这突出表明需要采取干预措施，包括改变生活方式、提供医疗保健和教育。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Environmental–genetic interactions in ageing and dementia across Latin America

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Environmental–genetic interactions in ageing and dementia across Latin America

Current dementia research has developed complex models of environmental–genetic interactions to better address multimodal disease phenotypes. New evidence highlights a stronger effect of social determinants of health than ancestry effects specific to Latin America and the Caribbean, which opens new agendas to address the diversity of these interactions in ageing and dementia. A new study on dementia prevalence in Latin America has found a stronger effect of social determinants of health than ancestry effects specific to this region, highlighting the need for interventions involving lifestyle changes, healthcare access and education.

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来源期刊

Nature Reviews Neurology 医学-临床神经学

CiteScore

29.90

自引率

0.80%

发文量

138

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Neurology aims to be the premier source of reviews and commentaries for the scientific and clinical communities we serve. We want to provide an unparalleled service to authors, referees, and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians working in the field of neurology. Our broad scope ensures that the work we publish reaches the widest possible audience. Our articles are authoritative, accessible, and enhanced with clearly understandable figures, tables, and other display items. This page gives more detail about the aims and scope of the journal.