结直肠癌肝转移和肺转移的不同克隆轨迹

IF 2 Q3 ONCOLOGY
Ofer N. Gofrit , Ben Gofrit , S. Nahum Goldberg , Aron Popovtzer , Jacob Sosna , Ayala Hubert
{"title":"结直肠癌肝转移和肺转移的不同克隆轨迹","authors":"Ofer N. Gofrit ,&nbsp;Ben Gofrit ,&nbsp;S. Nahum Goldberg ,&nbsp;Aron Popovtzer ,&nbsp;Jacob Sosna ,&nbsp;Ayala Hubert","doi":"10.1016/j.adcanc.2024.100122","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>The liver and lungs are the most common sites of colorectal cancer (CRC) metastases. Their involvement can take five different clinical scenarios: lung metastases only, liver metastases only, lung metastases before liver metastases, liver metastases before lung metastases and simultaneous lung and liver metastases. Using clinical and morphological data we studied the clonal trajectory of these scenarios.</p></div><div><h3>Materials and methods</h3><p>A total of 465 (CRC) patients with 7952 liver and 6406 lung metastases were evaluated. Metastases clinical route was deciphered from metastases number, timing, and linear/parallel ratio (LPR)- a computerized parameter used for deducing clonal trajectories. LPR of +1 suggest pure linear dissemination and −1 pure parallel.</p></div><div><h3>Results</h3><p>Lung-only metastases: high percentage of metachronous disease with a long lead time and a low LPR suggest parallel dissemination. Liver-only metastases: Rare metachronous disease with a short lead time, and a high LPR suggest linear spread. Lung-before-liver metastases: rare solitary metastasis, a median gap of 21 months between the organs, high lung and low liver LPRs suggest linear progression to the lungs and parallel dissemination to the liver. Liver-before-lung metastases: low liver and high lung LPRs and a median gap of 16.5 months between the organs suggest parallel dissemination to the liver and linear spread from the liver to the lungs. Simultaneous liver and lung metastases: rare solitary metastasis and similar and high LPRs suggest simultaneous linear progression to both organs.</p></div><div><h3>Conclusions</h3><p>CRC metastases have different dissemination trajectories in different clinical scenarios. This information can potentially impact on clinical management.</p></div>","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"11 ","pages":"Article 100122"},"PeriodicalIF":2.0000,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667394024000091/pdfft?md5=6643c17257215aca6ddde3347b246b1c&pid=1-s2.0-S2667394024000091-main.pdf","citationCount":"0","resultStr":"{\"title\":\"The varied clonal trajectory of liver and lung metastases of colorectal cancer\",\"authors\":\"Ofer N. Gofrit ,&nbsp;Ben Gofrit ,&nbsp;S. Nahum Goldberg ,&nbsp;Aron Popovtzer ,&nbsp;Jacob Sosna ,&nbsp;Ayala Hubert\",\"doi\":\"10.1016/j.adcanc.2024.100122\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>The liver and lungs are the most common sites of colorectal cancer (CRC) metastases. Their involvement can take five different clinical scenarios: lung metastases only, liver metastases only, lung metastases before liver metastases, liver metastases before lung metastases and simultaneous lung and liver metastases. Using clinical and morphological data we studied the clonal trajectory of these scenarios.</p></div><div><h3>Materials and methods</h3><p>A total of 465 (CRC) patients with 7952 liver and 6406 lung metastases were evaluated. Metastases clinical route was deciphered from metastases number, timing, and linear/parallel ratio (LPR)- a computerized parameter used for deducing clonal trajectories. LPR of +1 suggest pure linear dissemination and −1 pure parallel.</p></div><div><h3>Results</h3><p>Lung-only metastases: high percentage of metachronous disease with a long lead time and a low LPR suggest parallel dissemination. Liver-only metastases: Rare metachronous disease with a short lead time, and a high LPR suggest linear spread. Lung-before-liver metastases: rare solitary metastasis, a median gap of 21 months between the organs, high lung and low liver LPRs suggest linear progression to the lungs and parallel dissemination to the liver. Liver-before-lung metastases: low liver and high lung LPRs and a median gap of 16.5 months between the organs suggest parallel dissemination to the liver and linear spread from the liver to the lungs. Simultaneous liver and lung metastases: rare solitary metastasis and similar and high LPRs suggest simultaneous linear progression to both organs.</p></div><div><h3>Conclusions</h3><p>CRC metastases have different dissemination trajectories in different clinical scenarios. This information can potentially impact on clinical management.</p></div>\",\"PeriodicalId\":72083,\"journal\":{\"name\":\"Advances in cancer biology - metastasis\",\"volume\":\"11 \",\"pages\":\"Article 100122\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-07-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2667394024000091/pdfft?md5=6643c17257215aca6ddde3347b246b1c&pid=1-s2.0-S2667394024000091-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in cancer biology - metastasis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667394024000091\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in cancer biology - metastasis","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667394024000091","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景肝脏和肺部是结直肠癌(CRC)最常见的转移部位。它们受累的临床表现有五种:仅肺部转移、仅肝脏转移、先肺部转移后肝脏转移、先肝脏转移后肺部转移以及肺部和肝脏同时转移。我们利用临床和形态学数据研究了这些情况下的克隆轨迹。材料和方法共评估了 465 例(CRC)患者,其中肝转移 7952 例,肺转移 6406 例。根据转移灶的数量、时间和线性/平行比(LPR)--用于推断克隆轨迹的计算机参数--破译转移灶的临床路径。结果仅肺转移灶:转移灶比例高,时间长,LPR 低,表明是平行传播。仅肝转移:罕见的转移性疾病,前驱时间短,LPR 高,提示线性传播。先肺后肝转移:罕见的单发转移灶,各器官之间的中位间隔为21个月,肺部和肝脏的LPR较高,提示向肺部的线性进展和向肝脏的平行扩散。先肝后肺转移:肝脏和肺脏的 LPR 值较低,器官之间的中位间隔为 16.5 个月,表明肝脏平行扩散,肝脏向肺部的线性扩散。同时发生的肝肺转移:罕见的单发转移以及相似和较高的LPRs提示同时向两个器官的线性进展。这些信息可能会对临床治疗产生潜在影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The varied clonal trajectory of liver and lung metastases of colorectal cancer

The varied clonal trajectory of liver and lung metastases of colorectal cancer

Background

The liver and lungs are the most common sites of colorectal cancer (CRC) metastases. Their involvement can take five different clinical scenarios: lung metastases only, liver metastases only, lung metastases before liver metastases, liver metastases before lung metastases and simultaneous lung and liver metastases. Using clinical and morphological data we studied the clonal trajectory of these scenarios.

Materials and methods

A total of 465 (CRC) patients with 7952 liver and 6406 lung metastases were evaluated. Metastases clinical route was deciphered from metastases number, timing, and linear/parallel ratio (LPR)- a computerized parameter used for deducing clonal trajectories. LPR of +1 suggest pure linear dissemination and −1 pure parallel.

Results

Lung-only metastases: high percentage of metachronous disease with a long lead time and a low LPR suggest parallel dissemination. Liver-only metastases: Rare metachronous disease with a short lead time, and a high LPR suggest linear spread. Lung-before-liver metastases: rare solitary metastasis, a median gap of 21 months between the organs, high lung and low liver LPRs suggest linear progression to the lungs and parallel dissemination to the liver. Liver-before-lung metastases: low liver and high lung LPRs and a median gap of 16.5 months between the organs suggest parallel dissemination to the liver and linear spread from the liver to the lungs. Simultaneous liver and lung metastases: rare solitary metastasis and similar and high LPRs suggest simultaneous linear progression to both organs.

Conclusions

CRC metastases have different dissemination trajectories in different clinical scenarios. This information can potentially impact on clinical management.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Advances in cancer biology - metastasis
Advances in cancer biology - metastasis Cancer Research, Oncology
CiteScore
2.40
自引率
0.00%
发文量
0
审稿时长
103 days
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信