间充质干细胞及其外泌体在结直肠癌中的治疗潜力:从临床前走向临床之路

IF 2 Q3 ONCOLOGY
Zunaira Ali Baig , Farzana Shafqat , Iffat Mushtaq , Ummara Aslam , Asma Faryal , Ayesha Maryam
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引用次数: 0

摘要

大肠癌是全球发病率最高的癌症之一。全球越来越多的病例引发了人们对生活质量和存活率的担忧。关于疾病风险、进展和转移,包括遗传因素在内的各种因素已被广泛研究。然而,信号传导机制尚未得到广泛研究。目前已建立了多种治疗方法来对抗这种疾病,而间充质干细胞已成为一种重要的细胞治疗策略。间充质干细胞因其免疫调节功能而被视为各种癌症的潜在靶点。它们可以从骨髓、外周血、脐带和脂肪组织等多种人体组织中分离出来。据报道,从间充质干细胞中提取的外泌体可影响与结直肠癌相关的某些蛋白质的表达。本综述强调了间充质干细胞及其衍生的外泌体通过引起细胞毒性和细胞凋亡治疗癌症的潜力。此外,T细胞介导的外泌体调节有助于减少癌细胞的细胞增殖。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Therapeutic potential of mesenchymal stem cells and its exosomes in colorectal cancer: Paving way from preclinical towards clinical road

Colorectal cancer is one of the most prevalent cancers worldwide. An increasing number of cases around the globe are raising concerns for life quality and survival. Various factors including genetic drivers have been extensively studied regarding the disease risk, progression, and metastasis. However, the signaling mechanisms haven't been studied extensively yet. Various therapeutic methods have been established in combating the disease, and mesenchymal stem cells have come up as a crucial cell-based therapeutic strategy. Mesenchymal stem cells have been regarded as potential targets in various cancer types due to their immune-modulatory functions. They can be isolated from many body tissues including bone marrow, peripheral blood, umbilical cord, and adipose tissue. Exosomes derived from mesenchymal stem cells have been reported to affect the expression of certain proteins associated with colorectal cancer. The current review highlights the potential of mesenchymal stem cells and their derived exosomes in treating cancer by causing cytotoxicity and apoptosis. Further, T-cell mediated modulation of exosomes helps reduce the cellular proliferation in cancer cells.

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来源期刊
Advances in cancer biology - metastasis
Advances in cancer biology - metastasis Cancer Research, Oncology
CiteScore
2.40
自引率
0.00%
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审稿时长
103 days
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