Jinseung Kim , Ho-Joon Lee , Dong Ah Lee , Kang Min Park
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引用次数: 0
摘要
目的脉络丛的功能是产生脑脊液,而脑脊液对糖水系统功能至关重要。本研究旨在分析阻塞性睡眠呼吸暂停(OSA)患者与健康对照组之间脉络丛体积的差异,从而发现 OSA 患者的甘液系统功能障碍。所有参与者都接受了适合进行容积分析的三维 T1 加权脑成像。我们比较了 OSA 患者和健康对照组的脉络丛体积,并分析了 OSA 患者脉络丛体积与多导睡眠图结果之间的关联。结论本研究表明,与健康对照组相比,OSA 患者的脉络丛体积增大。这一发现可能与 OSA 患者的肾上腺系统功能障碍有关。
Choroid plexus enlargement in patients with obstructive sleep apnea
Objectives
The function of choroid plexus is to produce cerebrospinal fluid, which is critical for the glymphatic system function. In this study, we aimed to analyze the differences in choroid plexus volume between patients with obstructive sleep apnea (OSA) and healthy controls, with the goal of discovering the glymphatic system dysfunction in patients with OSA.
Methods
We prospectively enrolled 40 patients with OSA confirmed by polysomnography and 38 age- and sex-matched healthy controls. All participants underwent three-dimensional T1-weighted brain imaging, which was suitable for volumetric analysis. We compared choroid plexus volumes between patients with OSA and healthy controls, and analyzed the association between choroid plexus volume and polysomnographic findings in patients with OSA.
Results
Choroid plexus volumes were significantly larger in patients with OSA than in healthy controls (2.311 % vs. 2.096 %, p = 0.005). However, no significant association was detected between choroid plexus volume and polysomnographic findings.
Conclusion
This study demonstrated enlargement of the choroid plexus in patients with OSA compared with healthy controls. This finding could be related with glymphatic system dysfunction in patients with OSA.
期刊介绍:
Sleep Medicine aims to be a journal no one involved in clinical sleep medicine can do without.
A journal primarily focussing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine: neurology, clinical neurophysiology, internal medicine (particularly pulmonology and cardiology), psychology, psychiatry, sleep technology, pediatrics, neurosurgery, otorhinolaryngology, and dentistry.
The journal publishes the following types of articles: Reviews (also intended as a way to bridge the gap between basic sleep research and clinical relevance); Original Research Articles; Full-length articles; Brief communications; Controversies; Case reports; Letters to the Editor; Journal search and commentaries; Book reviews; Meeting announcements; Listing of relevant organisations plus web sites.