墨西哥甲型 H1N1 流感大流行后期和大流行后几年(2010-2014 年)患者人口统计学、病毒病原体、季节性和流感样病症结果的前瞻性队列研究

IF 1.5 Q4 INFECTIOUS DISEASES
Arturo Galindo-Fraga , Paola del Carmen Guerra-de-Blas , Ana A. Ortiz-Hernández , Kevin Rubenstein , Ana M. Ortega-Villa , Alejandra Ramírez-Venegas , Rafael Valdez-Vázquez , Sarbelio Moreno-Espinosa , Beatriz Llamosas-Gallardo , Santiago Pérez-Patrigeon , Daniel E. Noyola , Martín Magaña-Aquino , Ana Vilardell-Dávila , M. Lourdes Guerrero , John H. Powers , John Beigel , Guillermo M. Ruiz-Palacios , Mexican Emerging Infectious Disease Clinical Research Network
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引用次数: 0

摘要

目的由呼吸道病毒引起的流感样疾病(ILI)会导致各种呼吸道临床表现。ILI002 前瞻性观察性队列研究旨在描述甲型 H1N1 流感大流行和大流行后四个季节(2010-2014 年)中 ILI 患者的病毒病原体、季节性和预后。结果 在 5662 名登记患者中,64.9% 为成人,35.1% 为儿童。在检测到单一病原体的 5629 名参与者中,鼻病毒(20.2%)、流感病毒(11.2%)、呼吸道合胞病毒(RSV)(7.2%)和冠状病毒(6.8%)是最常见的病原体。有 14.5% 的病例合并感染;49.3% 的参与者需要住院治疗,尤其是 RSV 病例(42.9% 的成人和 89.6% 的儿童)。老年参与者和有合并症者的死亡率高出 2.8%。甲型 H1N1 流感的死亡率最高,但几乎一半的死者没有病原体。鼻病毒全年持续存在,而流感、冠状病毒和 RSV 则在较凉爽的月份达到高峰。这些发现可能有助于有关预防措施、疫苗接种、治疗和医疗管理等公共卫生政策的决策。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prospective cohort study of patient demographics, viral agents, seasonality, and outcomes of influenza-like illness in Mexico in the late H1N1-pandemic and post-pandemic years (2010-2014)

Objectives

Influenza-like illness (ILI) caused by respiratory viruses results in various respiratory clinical manifestations. The ILI002 prospective observational cohort study aimed to describe viral agents, seasonality, and outcomes of patients with ILI during four seasons in the influenza H1N1-pandemic and post-pandemic years (2010-2014).

Methods

Patients from six Mexican hospitals were enrolled from April 2010 to March 2014. Clinical data and nasopharyngeal swabs were obtained and tested for viral respiratory pathogens by real-time reverse-transcription polymerase chain reaction.

Results

Of the 5662 enrolled participants, 64.9% were adults and 35.1% were children. Among the 5629 participants with single-pathogen detection, rhinovirus (20.2%), influenza virus (11.2%), respiratory syncytial virus (RSV) (7.2%), and coronavirus (6.8%) were the most frequent pathogens. Co-infection occurred in 14.5% of cases; 49.3% of participants required hospitalization, particularly in RSV cases (42.9% adults, 89.6% children). The mortality rate was 2.8% higher among older adult participants and those with comorbidities. Influenza H1N1 had the highest mortality rate, yet almost half of the deceased had no pathogen. Rhinovirus persisted year-round, while influenza, coronavirus, and RSV peaked during cooler months.

Conclusions

Analyses showed that some viruses causing ILI may lead to severe disease and hospitalization irrespective of comorbidities. These findings may help in decision-making about public health policies on prevention measures, vaccination, treatment, and administration of health care.

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IJID regions
IJID regions Infectious Diseases
CiteScore
1.60
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