Xuedan Wang , Tingting Yang , Yidan Li , Chi Ma , Mengyu Yang , Qiuxia Qian , Guifen Ma , Hongbo Pei , Juanjuan Feng , Fanghong Yan , Xiangping Fan , Jianxun Cao , Yuxia Ma
{"title":"内在能力下降是老年人功能性残疾的预测因素：系统回顾和荟萃分析。","authors":"Xuedan Wang , Tingting Yang , Yidan Li , Chi Ma , Mengyu Yang , Qiuxia Qian , Guifen Ma , Hongbo Pei , Juanjuan Feng , Fanghong Yan , Xiangping Fan , Jianxun Cao , Yuxia Ma","doi":"10.1016/j.archger.2024.105550","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><p>To examine the predictive value of intrinsic capacity decline on functional disability among the elderly.</p></div><div><h3>Design</h3><p>Meta-analysis.</p></div><div><h3>Methods</h3><p>PubMed, EMBASE, Web of Science, The Cochrane Library, Wanfang Database, China Knowledge Resource Integrated Database (CNKI), Weipu Database (VIP), and Chinese Biomedical Database (CBM) were searched for relevant studies published from the inception until June 1, 2024. Stata 17.0 software was used to perform the meta-analysis. The methodological quality was evaluated using the Newcastle Ottawa Scale. The overall quality of evidence used GRADE guidelines to assess. A study protocol was registered in PROSPERO (CRD42023475461).</p></div><div><h3>Results</h3><p>The meta-analysis included 8 cohort studies including 9744 elderly people. Functional disability including ADL disability (<em>n</em> = 6) and IADL disability (<em>n</em> = 7). The results showed that intrinsic capacity decline could predict ADL disability (HR = 1.08, 95 %CI 1.04–1.12; <em>I</em><sup>2</sup> = 98.2 %, <em>P</em> < 0.001) and IADL disability (HR = 1.11, 95 %CI 1.05–1.17; <em>I</em><sup>2</sup> = 96.4 %, <em>P</em> < 0.001). The overall risk of bias was low. And the grade of evidence that assessed by GRADE guidelines was rated as moderate.</p></div><div><h3>Conclusions</h3><p>Intrinsic capacity decline is a predictor of functional disability in the elderly. Therefore, screening intrinsic capacity decline has important clinical implications for early identifying the risk of functional disability, which contributes to providing individualized interventions ahead of potential functional disability for the elderly, thereby preventing functional disability, improving the quality of life and promoting healthy aging.</p></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"126 ","pages":"Article 105550"},"PeriodicalIF":3.5000,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Intrinsic capacity decline as a predictor of functional disability in the elderly: A systematic review and meta-analysis\",\"authors\":\"Xuedan Wang , Tingting Yang , Yidan Li , Chi Ma , Mengyu Yang , Qiuxia Qian , Guifen Ma , Hongbo Pei , Juanjuan Feng , Fanghong Yan , Xiangping Fan , Jianxun Cao , Yuxia Ma\",\"doi\":\"10.1016/j.archger.2024.105550\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><p>To examine the predictive value of intrinsic capacity decline on functional disability among the elderly.</p></div><div><h3>Design</h3><p>Meta-analysis.</p></div><div><h3>Methods</h3><p>PubMed, EMBASE, Web of Science, The Cochrane Library, Wanfang Database, China Knowledge Resource Integrated Database (CNKI), Weipu Database (VIP), and Chinese Biomedical Database (CBM) were searched for relevant studies published from the inception until June 1, 2024. Stata 17.0 software was used to perform the meta-analysis. The methodological quality was evaluated using the Newcastle Ottawa Scale. The overall quality of evidence used GRADE guidelines to assess. A study protocol was registered in PROSPERO (CRD42023475461).</p></div><div><h3>Results</h3><p>The meta-analysis included 8 cohort studies including 9744 elderly people. Functional disability including ADL disability (<em>n</em> = 6) and IADL disability (<em>n</em> = 7). The results showed that intrinsic capacity decline could predict ADL disability (HR = 1.08, 95 %CI 1.04–1.12; <em>I</em><sup>2</sup> = 98.2 %, <em>P</em> < 0.001) and IADL disability (HR = 1.11, 95 %CI 1.05–1.17; <em>I</em><sup>2</sup> = 96.4 %, <em>P</em> < 0.001). The overall risk of bias was low. And the grade of evidence that assessed by GRADE guidelines was rated as moderate.</p></div><div><h3>Conclusions</h3><p>Intrinsic capacity decline is a predictor of functional disability in the elderly. Therefore, screening intrinsic capacity decline has important clinical implications for early identifying the risk of functional disability, which contributes to providing individualized interventions ahead of potential functional disability for the elderly, thereby preventing functional disability, improving the quality of life and promoting healthy aging.</p></div>\",\"PeriodicalId\":8306,\"journal\":{\"name\":\"Archives of gerontology and geriatrics\",\"volume\":\"126 \",\"pages\":\"Article 105550\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2024-06-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of gerontology and geriatrics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0167494324002267\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of gerontology and geriatrics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167494324002267","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Intrinsic capacity decline as a predictor of functional disability in the elderly: A systematic review and meta-analysis
Objectives
To examine the predictive value of intrinsic capacity decline on functional disability among the elderly.
Design
Meta-analysis.
Methods
PubMed, EMBASE, Web of Science, The Cochrane Library, Wanfang Database, China Knowledge Resource Integrated Database (CNKI), Weipu Database (VIP), and Chinese Biomedical Database (CBM) were searched for relevant studies published from the inception until June 1, 2024. Stata 17.0 software was used to perform the meta-analysis. The methodological quality was evaluated using the Newcastle Ottawa Scale. The overall quality of evidence used GRADE guidelines to assess. A study protocol was registered in PROSPERO (CRD42023475461).
Results
The meta-analysis included 8 cohort studies including 9744 elderly people. Functional disability including ADL disability (n = 6) and IADL disability (n = 7). The results showed that intrinsic capacity decline could predict ADL disability (HR = 1.08, 95 %CI 1.04–1.12; I2 = 98.2 %, P < 0.001) and IADL disability (HR = 1.11, 95 %CI 1.05–1.17; I2 = 96.4 %, P < 0.001). The overall risk of bias was low. And the grade of evidence that assessed by GRADE guidelines was rated as moderate.
Conclusions
Intrinsic capacity decline is a predictor of functional disability in the elderly. Therefore, screening intrinsic capacity decline has important clinical implications for early identifying the risk of functional disability, which contributes to providing individualized interventions ahead of potential functional disability for the elderly, thereby preventing functional disability, improving the quality of life and promoting healthy aging.
期刊介绍：
Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published.
Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.
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