Usama Sattar, Xiaorui Yin, Xianfu Luo, Chenglin Zhu, Zhongxiu Hu, Jon D Blumenfeld, Hanna Rennert, Alan Wu, Arindam RoyChoudhury, Gayle Salama, Martin R Prince
{"title":"常染色体显性多囊肾中脊髓脑膜憩室的发病率。","authors":"Usama Sattar, Xiaorui Yin, Xianfu Luo, Chenglin Zhu, Zhongxiu Hu, Jon D Blumenfeld, Hanna Rennert, Alan Wu, Arindam RoyChoudhury, Gayle Salama, Martin R Prince","doi":"10.3174/ajnr.A8407","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and purpose: </strong>Patients with autosomal dominant polycystic kidney disease (ADPKD) develop cysts in the kidneys, liver, spleen, pancreas, prostate, and arachnoid spaces. In addition, spinal meningeal diverticula have been reported. To determine whether spinal meningeal diverticula are associated with ADPKD, we compared their prevalence in subjects with ADPKD with a control cohort without ADPKD.</p><p><strong>Materials and methods: </strong>Subjects with ADPKD and age- and sex-matched controls without ADPKD undergoing abdominal MRI from the midthorax to the pelvis from 2003 to 2023 were retrospectively evaluated for spinal meningeal diverticula by 4 blinded observers. The prevalence of spinal meningeal diverticula in ADPKD was compared with that in control subjects, using <i>t</i> tests and correlated with clinical and laboratory data and MR imaging features, including cyst volumes and cyst counts.</p><p><strong>Results: </strong>Identification of spinal meningeal diverticula in ADPKD (<i>n</i> = 285, median age, 47; interquartile range [IQR], 37-56 years; 54% female) and control (<i>n</i> = 285, median age, 47; IQR, 37-57 years; 54% female) subjects had high interobserver agreement (pairwise Cohen κ = 0.74). Spinal meningeal diverticula were observed in 145 of 285 (51%) subjects with ADPKD compared with 66 of 285 (23%) control subjects without ADPKD (<i>P</i> < .001). Spinal meningeal diverticula in ADPKD were more prevalent in women (98 of 153 [64%]) than men (47 of 132 [36%], <i>P</i> < .001). The mean number of spinal meningeal diverticula per affected subject with ADPKD was 3.6 ± 2.9 compared with 2.4 ± 1.9 in controls with cysts (<i>P</i> < .001). The median volume (IQR, 25%-75%) of spinal meningeal diverticula was 400 (IQR, 210-740) mm<sup>3</sup> in those with ADPKD compared with 250 (IQR, 180-440) mm<sup>3</sup> in controls (<i>P</i> < .001). The mean spinal meningeal diverticulum diameter was greater in the sacrum (7.3 [SD, 4.1] mm) compared with thoracic (5.4 [SD, 1.8] mm) and lumbar spine (5.8 [SD, 2.0] mm), (<i>P</i> < .001), suggesting that hydrostatic pressure contributed to enlargement.</p><p><strong>Conclusions: </strong>ADPKD has a high prevalence of spinal meningeal diverticula, particularly in women.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prevalence of Spinal Meningeal Diverticula in Autosomal Dominant Polycystic Kidney Disease.\",\"authors\":\"Usama Sattar, Xiaorui Yin, Xianfu Luo, Chenglin Zhu, Zhongxiu Hu, Jon D Blumenfeld, Hanna Rennert, Alan Wu, Arindam RoyChoudhury, Gayle Salama, Martin R Prince\",\"doi\":\"10.3174/ajnr.A8407\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and purpose: </strong>Patients with autosomal dominant polycystic kidney disease (ADPKD) develop cysts in the kidneys, liver, spleen, pancreas, prostate, and arachnoid spaces. In addition, spinal meningeal diverticula have been reported. To determine whether spinal meningeal diverticula are associated with ADPKD, we compared their prevalence in subjects with ADPKD with a control cohort without ADPKD.</p><p><strong>Materials and methods: </strong>Subjects with ADPKD and age- and sex-matched controls without ADPKD undergoing abdominal MRI from the midthorax to the pelvis from 2003 to 2023 were retrospectively evaluated for spinal meningeal diverticula by 4 blinded observers. The prevalence of spinal meningeal diverticula in ADPKD was compared with that in control subjects, using <i>t</i> tests and correlated with clinical and laboratory data and MR imaging features, including cyst volumes and cyst counts.</p><p><strong>Results: </strong>Identification of spinal meningeal diverticula in ADPKD (<i>n</i> = 285, median age, 47; interquartile range [IQR], 37-56 years; 54% female) and control (<i>n</i> = 285, median age, 47; IQR, 37-57 years; 54% female) subjects had high interobserver agreement (pairwise Cohen κ = 0.74). Spinal meningeal diverticula were observed in 145 of 285 (51%) subjects with ADPKD compared with 66 of 285 (23%) control subjects without ADPKD (<i>P</i> < .001). Spinal meningeal diverticula in ADPKD were more prevalent in women (98 of 153 [64%]) than men (47 of 132 [36%], <i>P</i> < .001). The mean number of spinal meningeal diverticula per affected subject with ADPKD was 3.6 ± 2.9 compared with 2.4 ± 1.9 in controls with cysts (<i>P</i> < .001). The median volume (IQR, 25%-75%) of spinal meningeal diverticula was 400 (IQR, 210-740) mm<sup>3</sup> in those with ADPKD compared with 250 (IQR, 180-440) mm<sup>3</sup> in controls (<i>P</i> < .001). The mean spinal meningeal diverticulum diameter was greater in the sacrum (7.3 [SD, 4.1] mm) compared with thoracic (5.4 [SD, 1.8] mm) and lumbar spine (5.8 [SD, 2.0] mm), (<i>P</i> < .001), suggesting that hydrostatic pressure contributed to enlargement.</p><p><strong>Conclusions: </strong>ADPKD has a high prevalence of spinal meningeal diverticula, particularly in women.</p>\",\"PeriodicalId\":93863,\"journal\":{\"name\":\"AJNR. American journal of neuroradiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-11-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"AJNR. 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Prevalence of Spinal Meningeal Diverticula in Autosomal Dominant Polycystic Kidney Disease.
Background and purpose: Patients with autosomal dominant polycystic kidney disease (ADPKD) develop cysts in the kidneys, liver, spleen, pancreas, prostate, and arachnoid spaces. In addition, spinal meningeal diverticula have been reported. To determine whether spinal meningeal diverticula are associated with ADPKD, we compared their prevalence in subjects with ADPKD with a control cohort without ADPKD.
Materials and methods: Subjects with ADPKD and age- and sex-matched controls without ADPKD undergoing abdominal MRI from the midthorax to the pelvis from 2003 to 2023 were retrospectively evaluated for spinal meningeal diverticula by 4 blinded observers. The prevalence of spinal meningeal diverticula in ADPKD was compared with that in control subjects, using t tests and correlated with clinical and laboratory data and MR imaging features, including cyst volumes and cyst counts.
Results: Identification of spinal meningeal diverticula in ADPKD (n = 285, median age, 47; interquartile range [IQR], 37-56 years; 54% female) and control (n = 285, median age, 47; IQR, 37-57 years; 54% female) subjects had high interobserver agreement (pairwise Cohen κ = 0.74). Spinal meningeal diverticula were observed in 145 of 285 (51%) subjects with ADPKD compared with 66 of 285 (23%) control subjects without ADPKD (P < .001). Spinal meningeal diverticula in ADPKD were more prevalent in women (98 of 153 [64%]) than men (47 of 132 [36%], P < .001). The mean number of spinal meningeal diverticula per affected subject with ADPKD was 3.6 ± 2.9 compared with 2.4 ± 1.9 in controls with cysts (P < .001). The median volume (IQR, 25%-75%) of spinal meningeal diverticula was 400 (IQR, 210-740) mm3 in those with ADPKD compared with 250 (IQR, 180-440) mm3 in controls (P < .001). The mean spinal meningeal diverticulum diameter was greater in the sacrum (7.3 [SD, 4.1] mm) compared with thoracic (5.4 [SD, 1.8] mm) and lumbar spine (5.8 [SD, 2.0] mm), (P < .001), suggesting that hydrostatic pressure contributed to enlargement.
Conclusions: ADPKD has a high prevalence of spinal meningeal diverticula, particularly in women.
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