HSC70/HSPA8在病毒进入中的机制和复杂作用

IF 2.5 4区医学 Q3 VIROLOGY

Virus research Pub Date : 2024-07-17 DOI:10.1016/j.virusres.2024.199433

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引用次数: 0

摘要

病毒进入宿主细胞的过程十分复杂，涉及细胞膜分子组织、病毒蛋白、受体分子相互作用和细胞信号传导等多个方面。大多数病毒的摄取依赖于内吞作用，当病毒到达适当位置时，就会从囊泡中释放出来，进行解包被，并释放其基因组。热休克同源蛋白 70（HSC70）：又称 HSPA8，是一种参与介导凝集素介导的内吞作用（CME）的蛋白质，参与了各种病毒的进入过程。在这篇微型综述中，我们的目标是总结 HSC70 在病毒进入过程中的功能。了解 HSC70 与病毒蛋白的相互作用网络有助于为针对病毒感染的靶向治疗策略提供新的方向。

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Mechanism and complex roles of HSC70/HSPA8 in viral entry

The process of viruses entering host cells is complex, involving multiple aspects of the molecular organization of the cell membrane, viral proteins, the interaction of receptor molecules, and cellular signaling. Most viruses depend on endocytosis for uptake, when viruses reach the appropriate location, they are released from the vesicles, undergo uncoating, and release their genomes. Heat shock cognate protein 70(HSC70): also known as HSPA8, a protein involved in mediating clathrin-mediated endocytosis (CME), is involved in various viral entry processes. In this mini-review, our goal is to provide a summary of the function of HSC70 in viral entry. Understanding the interaction networks of HSC70 with viral proteins helps to provide new directions for targeted therapeutic strategies against viral infections.

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来源期刊

Virus research 医学-病毒学

CiteScore

9.50

自引率

2.00%

发文量

239

审稿时长

43 days

期刊介绍： Virus Research provides a means of fast publication for original papers on fundamental research in virology. Contributions on new developments concerning virus structure, replication, pathogenesis and evolution are encouraged. These include reports describing virus morphology, the function and antigenic analysis of virus structural components, virus genome structure and expression, analysis on virus replication processes, virus evolution in connection with antiviral interventions, effects of viruses on their host cells, particularly on the immune system, and the pathogenesis of virus infections, including oncogene activation and transduction.