植物是如何通过 UbiA 前酰基转移酶进化出特殊酚类代谢物的前酰基化的?

IF 8.3 2区 生物学 Q1 PLANT SCIENCES
Ryosuke Munakata, Kazufumi Yazaki
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引用次数: 0

摘要

植物界有超过 4000 种植物含有链烯基酚类化合物,其中大部分是化学多样性极高的特殊代谢物。从各种药用植物中发现了许多具有药理活性的化合物,其中的链烯基残基在这些活性中起着关键作用。在过去的二十年中,对负责其生物合成的异戊烯基转移酶(PTs)进行了深入研究。这些酶是膜结合蛋白,属于 UbiA 超家族,从细菌到人类都有,特别是那些参与植物特化代谢的酶对底物和产物都有严格的特异性。本文综述了植物 UbiA PTs 的酶学特征,包括 C-和 O-异戊烯化、分子进化以及 UbiA PTs 在合成生物学中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
How did plants evolve the prenylation of specialized phenolic metabolites by means of UbiA prenyltransferases?

Prenylated phenolics occur in over 4000 species in the plant kingdom, most of which are known as specialized metabolites with high chemical diversity. Many of them have been identified as pharmacologically active compounds from various medicinal plants, in which prenyl residues play a key role in these activities. Prenyltransferases (PTs) responsible for their biosynthesis have been intensively studied in the last two decades. These enzymes are membrane-bound proteins belonging to the UbiA superfamily that occurs from bacteria to humans, and in particular those involved in plant specialized metabolism show strict specificities for both substrates and products. This article reviews the enzymatic features of plant UbiA PTs, including C- and O-prenylation, molecular evolution, and application of UbiA PTs in synthetic biology.

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来源期刊
Current opinion in plant biology
Current opinion in plant biology 生物-植物科学
CiteScore
16.30
自引率
3.20%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Current Opinion in Plant Biology builds on Elsevier's reputation for excellence in scientific publishing and long-standing commitment to communicating high quality reproducible research. It is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy - of editorial excellence, high-impact, and global reach - to ensure they are a widely read resource that is integral to scientists' workflow.
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