Jiseung Kang , Hyeri Lee , Jaeyu Park , Hyeon Jin Kim , Rosie Kwon , Sunyoung Kim , Guillaume Fond , Laurent Boyer , Masoud Rahmati , Lee Smith , Christa J. Nehs , Yejun Son , Soeun Kim , Hayeon Lee , Jinseok Lee , Min Seo Kim , Tae Kim , Dong Keon Yon
{"title":"双相情感障碍患者的并发症对身体健康的影响:对系统综述和荟萃分析的总体回顾。","authors":"Jiseung Kang , Hyeri Lee , Jaeyu Park , Hyeon Jin Kim , Rosie Kwon , Sunyoung Kim , Guillaume Fond , Laurent Boyer , Masoud Rahmati , Lee Smith , Christa J. Nehs , Yejun Son , Soeun Kim , Hayeon Lee , Jinseok Lee , Min Seo Kim , Tae Kim , Dong Keon Yon","doi":"10.1016/j.ajp.2024.104138","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Although several meta-analyses have examined the association between bipolar disorder (BD) and its comorbid health outcomes, this evidence has not been comprehensively assembled.</p></div><div><h3>Objective</h3><p>We aimed to systematically review existing meta-analyses based on multiple physical outcomes and validate the evidence level by examining the existing certainty of evidence.</p></div><div><h3>Methods</h3><p>We systematically searched databases, including PubMed/MEDLINE, Embase, Google Scholar, and CINAHL, for articles published up to July 2023. We included meta-analyses of cohort, case-control, and/or cross-sectional studies investigating any comorbid health outcomes in patients with BD. We conducted quality assessments of the included meta-analysis using AMSTAR2. The credibility of findings was categorized into five levels of class and quality of evidence (CE), including convincing, highly suggestive, suggestive, weak, or not significant.</p></div><div><h3>Results</h3><p>We analyzed 12 meta-analyses, including 145 original articles, covering 14 unique health outcomes with over 60 million participants across 29 countries and five continents. Among 14 health outcomes, BD was significantly associated with eight comorbid health outcomes, including dementia (equivalent odds ratio [eOR], 2.96 [95 % confidence intervals {CI}, 1.69–5.17]; CE=suggestive), Parkinson’s disease (3.35 [1.72–6.53]; CE=suggestive), asthma (1.86 [1.42–2.42]; CE=weak), toxoplasmosis (1.69 [1.21–2.37]; CE=weak), hypertension (1.28 [1.02–1.60]; CE=convincing), breast cancer (1.33 [1.15–1.55]; CE=weak), obesity (1.64 [1.30–1.99]; CE=suggestive), and type 2 diabetes mellitus (1.98 [1.55–2.52]; CE=weak).</p></div><div><h3>Conclusion</h3><p>Individuals with BD are predisposed to numerous comorbid physical conditions, though these links are supported by various evidence levels and necessitate further studies. It is imperative that physicians be aware of these potential comorbidities in patients with BD and take proactive measures to manage them.</p></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":null,"pages":null},"PeriodicalIF":3.8000,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comorbid physical health outcomes in patients with bipolar disorder: An umbrella review of systematic reviews and meta-analyses\",\"authors\":\"Jiseung Kang , Hyeri Lee , Jaeyu Park , Hyeon Jin Kim , Rosie Kwon , Sunyoung Kim , Guillaume Fond , Laurent Boyer , Masoud Rahmati , Lee Smith , Christa J. Nehs , Yejun Son , Soeun Kim , Hayeon Lee , Jinseok Lee , Min Seo Kim , Tae Kim , Dong Keon Yon\",\"doi\":\"10.1016/j.ajp.2024.104138\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Although several meta-analyses have examined the association between bipolar disorder (BD) and its comorbid health outcomes, this evidence has not been comprehensively assembled.</p></div><div><h3>Objective</h3><p>We aimed to systematically review existing meta-analyses based on multiple physical outcomes and validate the evidence level by examining the existing certainty of evidence.</p></div><div><h3>Methods</h3><p>We systematically searched databases, including PubMed/MEDLINE, Embase, Google Scholar, and CINAHL, for articles published up to July 2023. We included meta-analyses of cohort, case-control, and/or cross-sectional studies investigating any comorbid health outcomes in patients with BD. We conducted quality assessments of the included meta-analysis using AMSTAR2. The credibility of findings was categorized into five levels of class and quality of evidence (CE), including convincing, highly suggestive, suggestive, weak, or not significant.</p></div><div><h3>Results</h3><p>We analyzed 12 meta-analyses, including 145 original articles, covering 14 unique health outcomes with over 60 million participants across 29 countries and five continents. Among 14 health outcomes, BD was significantly associated with eight comorbid health outcomes, including dementia (equivalent odds ratio [eOR], 2.96 [95 % confidence intervals {CI}, 1.69–5.17]; CE=suggestive), Parkinson’s disease (3.35 [1.72–6.53]; CE=suggestive), asthma (1.86 [1.42–2.42]; CE=weak), toxoplasmosis (1.69 [1.21–2.37]; CE=weak), hypertension (1.28 [1.02–1.60]; CE=convincing), breast cancer (1.33 [1.15–1.55]; CE=weak), obesity (1.64 [1.30–1.99]; CE=suggestive), and type 2 diabetes mellitus (1.98 [1.55–2.52]; CE=weak).</p></div><div><h3>Conclusion</h3><p>Individuals with BD are predisposed to numerous comorbid physical conditions, though these links are supported by various evidence levels and necessitate further studies. It is imperative that physicians be aware of these potential comorbidities in patients with BD and take proactive measures to manage them.</p></div>\",\"PeriodicalId\":8543,\"journal\":{\"name\":\"Asian journal of psychiatry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2024-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian journal of psychiatry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1876201824002314\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian journal of psychiatry","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1876201824002314","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Comorbid physical health outcomes in patients with bipolar disorder: An umbrella review of systematic reviews and meta-analyses
Background
Although several meta-analyses have examined the association between bipolar disorder (BD) and its comorbid health outcomes, this evidence has not been comprehensively assembled.
Objective
We aimed to systematically review existing meta-analyses based on multiple physical outcomes and validate the evidence level by examining the existing certainty of evidence.
Methods
We systematically searched databases, including PubMed/MEDLINE, Embase, Google Scholar, and CINAHL, for articles published up to July 2023. We included meta-analyses of cohort, case-control, and/or cross-sectional studies investigating any comorbid health outcomes in patients with BD. We conducted quality assessments of the included meta-analysis using AMSTAR2. The credibility of findings was categorized into five levels of class and quality of evidence (CE), including convincing, highly suggestive, suggestive, weak, or not significant.
Results
We analyzed 12 meta-analyses, including 145 original articles, covering 14 unique health outcomes with over 60 million participants across 29 countries and five continents. Among 14 health outcomes, BD was significantly associated with eight comorbid health outcomes, including dementia (equivalent odds ratio [eOR], 2.96 [95 % confidence intervals {CI}, 1.69–5.17]; CE=suggestive), Parkinson’s disease (3.35 [1.72–6.53]; CE=suggestive), asthma (1.86 [1.42–2.42]; CE=weak), toxoplasmosis (1.69 [1.21–2.37]; CE=weak), hypertension (1.28 [1.02–1.60]; CE=convincing), breast cancer (1.33 [1.15–1.55]; CE=weak), obesity (1.64 [1.30–1.99]; CE=suggestive), and type 2 diabetes mellitus (1.98 [1.55–2.52]; CE=weak).
Conclusion
Individuals with BD are predisposed to numerous comorbid physical conditions, though these links are supported by various evidence levels and necessitate further studies. It is imperative that physicians be aware of these potential comorbidities in patients with BD and take proactive measures to manage them.
期刊介绍:
The Asian Journal of Psychiatry serves as a comprehensive resource for psychiatrists, mental health clinicians, neurologists, physicians, mental health students, and policymakers. Its goal is to facilitate the exchange of research findings and clinical practices between Asia and the global community. The journal focuses on psychiatric research relevant to Asia, covering preclinical, clinical, service system, and policy development topics. It also highlights the socio-cultural diversity of the region in relation to mental health.