外泌体：生物功能、诊断和靶向治疗应用及临床试验综述

IF 9 2区医学 Q1 CELL BIOLOGY

Journal of Biomedical Science Pub Date : 2024-07-11 DOI:10.1186/s12929-024-01055-0

Yi-Fan Chen, Frank Luh, Yuan-Soon Ho, Yun Yen

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引用次数: 0

摘要

外泌体是所有细胞产生的细胞外囊泡，它们携带核酸、蛋白质、脂质和代谢物。它们介导细胞间的物质交换，从而影响受体细胞的生物特性和活性。在这篇综述中，我们将简要讨论外泌体的组成和外泌体的分离。我们还回顾了外泌体在癌症生物学中的临床应用以及外泌体介导的靶向给药系统的策略。最后，我们还讨论了外泌体在癌症治疗方面的应用实践和文献。

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Exosomes: a review of biologic function, diagnostic and targeted therapy applications, and clinical trials

Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids, proteins, lipids, and metabolites. They mediate the exchange of substances between cells,thereby affecting biological properties and activities of recipient cells. In this review, we briefly discuss the composition of exocomes and exosome isolation. We also review the clinical applications of exosomes in cancer biology as well as strategies in exosome-mediated targeted drug delivery systems. Finally, the application of exosomes in the context of cancer therapeutics both in practice and literature are discussed.

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来源期刊

Journal of Biomedical Science 医学-医学：研究与实验

CiteScore

18.50

自引率

0.90%

发文量

审稿时长

1 months

期刊介绍： The Journal of Biomedical Science is an open access, peer-reviewed journal that focuses on fundamental and molecular aspects of basic medical sciences. It emphasizes molecular studies of biomedical problems and mechanisms. The National Science and Technology Council (NSTC), Taiwan supports the journal and covers the publication costs for accepted articles. The journal aims to provide an international platform for interdisciplinary discussions and contribute to the advancement of medicine. It benefits both readers and authors by accelerating the dissemination of research information and providing maximum access to scholarly communication. All articles published in the Journal of Biomedical Science are included in various databases such as Biological Abstracts, BIOSIS, CABI, CAS, Citebase, Current contents, DOAJ, Embase, EmBiology, and Global Health, among others.