Fgfbp1+ 细胞：上隐窝肠上皮再生

IF 45.9 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-11 DOI:10.1038/s41575-024-00965-6

Jordan Hindson

引用次数: 0

摘要

发表在《细胞》（Cell）杂志上的一项新研究发现了肠上皮上隐窝中的一种新型再生干细胞群。研究利用时间分辨命运图谱和系谱追踪显示，这些表达Fgfbp1的细胞与Lgr5+细胞不同，它们能产生Lgr5+隐窝基底柱状细胞和所有其他肠系--并且在Lgr5+细胞耗尽后继续再生肠上皮。此外，小鼠 Fgfbp1 条件性基因敲除实验表明，上隐窝干细胞表达 FGFBP1 对于隐窝再生和肠上皮稳态至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Fgfbp1+ cells: upper crypt intestinal epithelial regeneration

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来源期刊

Nature Reviews Gastroenterology &Hepatology 医学-胃肠肝病学

CiteScore

52.30

自引率

0.60%

发文量

147

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.