Lu Li, Yadi Ren, Zeyu Wang, Yanqing Niu, Ying Zhao, Xiaherezhati Aihaiti, Yinglan Ji, Man Li
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Significant and positive association was found for <i>H. pylori</i> infection with anxiety (OR 2.49, 95% CI 1.83–3.39), but not depression (OR 1.40, 95% CI 0.75–2.58). Subgroup analysis from study design noted a significant positive association between <i>H. pylori</i> infection and anxiety (case-control and cross-sectional study, OR 2.36, 95% CI 1.65–3.38; cohort study, RR 1.72, 95% CI 1.28–2.32). The similar trend among studies used the Self-Rating Anxiety Scale (OR 2.43, 95% CI 1.78–3.32) and other questionnaires (OR 2.41, 95% CI 1.50–3.87) have been observed. However, subgroup analysis of the association between <i>H. pylori</i> infection and depression yields different results. Subgroup analysis from cohort studies noted a significant association between <i>H. pylori</i> infection and depression (RR 1.99, 95% CI 1.33–2.99), but not case-control and cross-sectional studies (OR 1.20, 95% CI 0.59–2.46). A significant positive association has been observed among studies used the Self-Rating Depression Scale (OR 2.03, 95% CI 1.11–3.70), as opposed to studies using other questionnaires (OR 1.03, 95% CI 0.31–3.44). <i>Conclusion</i>. This meta-analysis provide the support that a significant positive association between <i>H. pylori</i> infection and anxiety disorders. However, the association between <i>H. pylori</i> infection and depression appears to be insignificant.</p>\n </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2024 1","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/9247586","citationCount":"0","resultStr":"{\"title\":\"Association of Helicobacter pylori Infection with Depression and Anxiety: A Systematic Review and Meta-Analysis\",\"authors\":\"Lu Li, Yadi Ren, Zeyu Wang, Yanqing Niu, Ying Zhao, Xiaherezhati Aihaiti, Yinglan Ji, Man Li\",\"doi\":\"10.1155/2024/9247586\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n <p><i>Introduction</i>. The association between <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection and depression and anxiety has been reported in the literature. The aim of this meta-analysis is to investigate the association of <i>H. pylori</i> infection with depression and anxiety. <i>Methods</i>. A systematic search was conducted in PubMed, Web of Science, Embase, and Chinese databases for observational studies that reported the incidence or prevalence of depression and anxiety in patients with <i>H. pylori</i> infection. We conducted meta-analysis with a random-effects model. <i>Results</i>. A total of twelve studies were included in this meta-analysis. Significant and positive association was found for <i>H. pylori</i> infection with anxiety (OR 2.49, 95% CI 1.83–3.39), but not depression (OR 1.40, 95% CI 0.75–2.58). Subgroup analysis from study design noted a significant positive association between <i>H. pylori</i> infection and anxiety (case-control and cross-sectional study, OR 2.36, 95% CI 1.65–3.38; cohort study, RR 1.72, 95% CI 1.28–2.32). The similar trend among studies used the Self-Rating Anxiety Scale (OR 2.43, 95% CI 1.78–3.32) and other questionnaires (OR 2.41, 95% CI 1.50–3.87) have been observed. However, subgroup analysis of the association between <i>H. pylori</i> infection and depression yields different results. Subgroup analysis from cohort studies noted a significant association between <i>H. pylori</i> infection and depression (RR 1.99, 95% CI 1.33–2.99), but not case-control and cross-sectional studies (OR 1.20, 95% CI 0.59–2.46). A significant positive association has been observed among studies used the Self-Rating Depression Scale (OR 2.03, 95% CI 1.11–3.70), as opposed to studies using other questionnaires (OR 1.03, 95% CI 0.31–3.44). <i>Conclusion</i>. This meta-analysis provide the support that a significant positive association between <i>H. pylori</i> infection and anxiety disorders. 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引用次数: 0
摘要
简介幽门螺杆菌（H. pylori）感染与抑郁和焦虑之间的关系已有文献报道。本荟萃分析旨在研究幽门螺杆菌感染与抑郁和焦虑之间的关系。研究方法我们在 PubMed、Web of Science、Embase 和中文数据库中对报道幽门螺杆菌感染患者抑郁和焦虑发生率或流行率的观察性研究进行了系统检索。我们采用随机效应模型进行了荟萃分析。结果本次荟萃分析共纳入了 12 项研究。研究发现，幽门螺杆菌感染与焦虑（OR 2.49，95% CI 1.83-3.39）有显著的正相关，但与抑郁（OR 1.40，95% CI 0.75-2.58）无显著相关。根据研究设计进行的分组分析表明，幽门螺杆菌感染与焦虑之间存在显著的正相关关系（病例对照和横断面研究，OR 2.36，95% CI 1.65-3.38；队列研究，RR 1.72，95% CI 1.28-2.32）。使用焦虑自评量表（OR 2.43，95% CI 1.78-3.32）和其他问卷（OR 2.41，95% CI 1.50-3.87）进行的研究也观察到类似的趋势。然而，对幽门螺杆菌感染与抑郁之间的关系进行的亚组分析却得出了不同的结果。对队列研究进行的亚组分析表明，幽门螺杆菌感染与抑郁之间存在显著关联（RR 1.99，95% CI 1.33-2.99），但病例对照和横断面研究（OR 1.20，95% CI 0.59-2.46）则未发现这种关联。使用抑郁自评量表的研究（OR 2.03，95% CI 1.11-3.70）与使用其他问卷的研究（OR 1.03，95% CI 0.31-3.44）相比，观察到了明显的正相关。结论这项荟萃分析支持幽门螺杆菌感染与焦虑症之间存在显著的正相关。然而，幽门螺杆菌感染与抑郁症之间的关系似乎并不显著。
Association of Helicobacter pylori Infection with Depression and Anxiety: A Systematic Review and Meta-Analysis
Introduction. The association between Helicobacter pylori (H. pylori) infection and depression and anxiety has been reported in the literature. The aim of this meta-analysis is to investigate the association of H. pylori infection with depression and anxiety. Methods. A systematic search was conducted in PubMed, Web of Science, Embase, and Chinese databases for observational studies that reported the incidence or prevalence of depression and anxiety in patients with H. pylori infection. We conducted meta-analysis with a random-effects model. Results. A total of twelve studies were included in this meta-analysis. Significant and positive association was found for H. pylori infection with anxiety (OR 2.49, 95% CI 1.83–3.39), but not depression (OR 1.40, 95% CI 0.75–2.58). Subgroup analysis from study design noted a significant positive association between H. pylori infection and anxiety (case-control and cross-sectional study, OR 2.36, 95% CI 1.65–3.38; cohort study, RR 1.72, 95% CI 1.28–2.32). The similar trend among studies used the Self-Rating Anxiety Scale (OR 2.43, 95% CI 1.78–3.32) and other questionnaires (OR 2.41, 95% CI 1.50–3.87) have been observed. However, subgroup analysis of the association between H. pylori infection and depression yields different results. Subgroup analysis from cohort studies noted a significant association between H. pylori infection and depression (RR 1.99, 95% CI 1.33–2.99), but not case-control and cross-sectional studies (OR 1.20, 95% CI 0.59–2.46). A significant positive association has been observed among studies used the Self-Rating Depression Scale (OR 2.03, 95% CI 1.11–3.70), as opposed to studies using other questionnaires (OR 1.03, 95% CI 0.31–3.44). Conclusion. This meta-analysis provide the support that a significant positive association between H. pylori infection and anxiety disorders. However, the association between H. pylori infection and depression appears to be insignificant.
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