Shang Dai, Binqiang Wang, Rui Ye, Dong Zhang, Zhenming Xie, Ning Yu, Chunhui Cai, Cheng Huang, Jie Zhao, Furong Zhang, Yuejin Hua, Ye Zhao, Ruhong Zhou, Bing Tian
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Structural Evolution of Bacterial Polyphosphate Degradation Enzyme for Phosphorus Cycling (Adv. Sci. 26/2024)
Linker-Based Structural Evolution
Phosphorus is a key element in the process of life origin. Polyphosphate is a phosphate “pool” in bacteria. In article number 2309602, Bing Tian, Ruhong Zhou, Shang Dai, and their co-workers demonstrate an interdomain linker-based exopolyphosphatase (PPX) structural evolution in bacteria. The length of α-linker in PPX, which involves phosphate cycling, is varied among bacteria and has impacts on protein's conformation and quaternary structure, thus poses an impact on enzyme activity and thermostability. The results suggest a potential relationship between PPX structural evolution and bacterial environmental adaptability, which shed light on enzymatic adaption for phosphorus cycling during natural evolution and rational design of the enzyme.
期刊介绍：
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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