铋活性药物成分--没食子酸铋(iii)和柠檬酸铋的机械化学合成†。

Daniel Szczerba, Jean-Louis Do, Davin Tan, Hatem M. Titi, Nicolas Geoffroy, María del Carmen Marco de Lucas, Julien Boudon, Ivan Halasz, Tomislav Friščić and Simon A. J. Kimber
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引用次数: 0

摘要

几个世纪以来,有机铋化合物一直是众所周知的医用物质,如今仍在医学中继续使用。铋活性药物成分(API)被用作消化辅助剂,包括用于抗幽门螺旋杆菌,并具有抗病毒特性。在此,我们报告了没食子酸铋和柠檬酸铋的机械化学合成。此外,我们还重温了之前报道的二水杨酸铋和三水杨酸铋(III)的机械化学合成。对于结构未知的柠檬酸铋,我们的研究表明,水合作用诱导了向大(可能是立方)单胞的可逆转变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Mechanochemical synthesis of bismuth active pharmaceutical ingredients, bismuth(iii) gallate and bismuth citrate†

Mechanochemical synthesis of bismuth active pharmaceutical ingredients, bismuth(iii) gallate and bismuth citrate†

Organobismuth compounds have been known for centuries as substances of medical interest, and continue to be used in medicine today. Bismuth active pharmaceutical ingredients (APIs) are used as digestive aids, including in combating Helicobacter pylori, showing antiviral properties. Here we report the mechanochemical synthesis of bismuth gallate and bismuth citrate. In addition, we revisit the previously reported mechanochemical synthesis of bismuth(III) di- and trisalicylate. In the case of bismuth citrate, which has an unknown structure, we show that hydration induces a reversible transformation to a large (possibly cubic) unit cell.

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