Runan Li , Hongyong Xiang , Qin Liang , Yan Zhou , Xuenan Ma , Danming Chao , Meiying Xin , Hongming Yuan , Xiaoteng Jia
{"title":"针对生物膜微环境设计治疗用锌电池的电化学特性,促进糖尿病伤口愈合","authors":"Runan Li , Hongyong Xiang , Qin Liang , Yan Zhou , Xuenan Ma , Danming Chao , Meiying Xin , Hongming Yuan , Xiaoteng Jia","doi":"10.1016/j.nanoen.2024.109946","DOIUrl":null,"url":null,"abstract":"<div><p>The bacterial-infected diabetic wound poses a heavy burden on the patient and society. The current electrical antibiotic administration avoids drug resistance associated with antibiotics, but their development is restricted by the complex wound microenvironments. Here we propose a new therapeutic Zn battery by rationally tailoring the electrochemistry for the wound microenvironment modulation. Poly(3,4-ethylenedioxythiophene) (PEDOT) polyelectrolyte hydrogel epidermal cathode demonstrates high adhesion strength and low interfacial impedance, enabling efficient delivery of endogenous bioelectronic cues to the wound. This wearable Zn battery combines capabilities of prolonged tissue regeneration and biofilm deconstruction while retaining 52 % discharge capacity after ten times oxygen charging. The electrochemical products and discharging microcurrent are effective in bacterial sterilization and biofilm deconstruction without impairing fibroblast growth via the synergic effects of polyelectrolyte biointerface, oxidative stress in the bacterial cell, and depletion of glutathione in the microenvironment. This battery-induced electrochemical stimulation demonstrates accelerated diabetic wound healing by guiding fibroblast migration, managing inflammation, and eliminating wound infections. This work provides a unique modality to modulate the biofilm environment through electrochemistry design for bacterial-infected chronic wound healing.</p></div>","PeriodicalId":394,"journal":{"name":"Nano Energy","volume":null,"pages":null},"PeriodicalIF":16.8000,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Engineering the electrochemistry of a therapeutic Zn battery toward biofilm microenvironment for diabetic wound healing\",\"authors\":\"Runan Li , Hongyong Xiang , Qin Liang , Yan Zhou , Xuenan Ma , Danming Chao , Meiying Xin , Hongming Yuan , Xiaoteng Jia\",\"doi\":\"10.1016/j.nanoen.2024.109946\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The bacterial-infected diabetic wound poses a heavy burden on the patient and society. The current electrical antibiotic administration avoids drug resistance associated with antibiotics, but their development is restricted by the complex wound microenvironments. Here we propose a new therapeutic Zn battery by rationally tailoring the electrochemistry for the wound microenvironment modulation. Poly(3,4-ethylenedioxythiophene) (PEDOT) polyelectrolyte hydrogel epidermal cathode demonstrates high adhesion strength and low interfacial impedance, enabling efficient delivery of endogenous bioelectronic cues to the wound. This wearable Zn battery combines capabilities of prolonged tissue regeneration and biofilm deconstruction while retaining 52 % discharge capacity after ten times oxygen charging. The electrochemical products and discharging microcurrent are effective in bacterial sterilization and biofilm deconstruction without impairing fibroblast growth via the synergic effects of polyelectrolyte biointerface, oxidative stress in the bacterial cell, and depletion of glutathione in the microenvironment. This battery-induced electrochemical stimulation demonstrates accelerated diabetic wound healing by guiding fibroblast migration, managing inflammation, and eliminating wound infections. This work provides a unique modality to modulate the biofilm environment through electrochemistry design for bacterial-infected chronic wound healing.</p></div>\",\"PeriodicalId\":394,\"journal\":{\"name\":\"Nano Energy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.8000,\"publicationDate\":\"2024-07-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nano Energy\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2211285524006955\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Energy","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211285524006955","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Engineering the electrochemistry of a therapeutic Zn battery toward biofilm microenvironment for diabetic wound healing
The bacterial-infected diabetic wound poses a heavy burden on the patient and society. The current electrical antibiotic administration avoids drug resistance associated with antibiotics, but their development is restricted by the complex wound microenvironments. Here we propose a new therapeutic Zn battery by rationally tailoring the electrochemistry for the wound microenvironment modulation. Poly(3,4-ethylenedioxythiophene) (PEDOT) polyelectrolyte hydrogel epidermal cathode demonstrates high adhesion strength and low interfacial impedance, enabling efficient delivery of endogenous bioelectronic cues to the wound. This wearable Zn battery combines capabilities of prolonged tissue regeneration and biofilm deconstruction while retaining 52 % discharge capacity after ten times oxygen charging. The electrochemical products and discharging microcurrent are effective in bacterial sterilization and biofilm deconstruction without impairing fibroblast growth via the synergic effects of polyelectrolyte biointerface, oxidative stress in the bacterial cell, and depletion of glutathione in the microenvironment. This battery-induced electrochemical stimulation demonstrates accelerated diabetic wound healing by guiding fibroblast migration, managing inflammation, and eliminating wound infections. This work provides a unique modality to modulate the biofilm environment through electrochemistry design for bacterial-infected chronic wound healing.
期刊介绍:
Nano Energy is a multidisciplinary, rapid-publication forum of original peer-reviewed contributions on the science and engineering of nanomaterials and nanodevices used in all forms of energy harvesting, conversion, storage, utilization and policy. Through its mixture of articles, reviews, communications, research news, and information on key developments, Nano Energy provides a comprehensive coverage of this exciting and dynamic field which joins nanoscience and nanotechnology with energy science. The journal is relevant to all those who are interested in nanomaterials solutions to the energy problem.
Nano Energy publishes original experimental and theoretical research on all aspects of energy-related research which utilizes nanomaterials and nanotechnology. Manuscripts of four types are considered: review articles which inform readers of the latest research and advances in energy science; rapid communications which feature exciting research breakthroughs in the field; full-length articles which report comprehensive research developments; and news and opinions which comment on topical issues or express views on the developments in related fields.