基于小分子的荧光化学传感器在生物成像中的应用综述。

IF 2.6 4区 化学 Q2 BIOCHEMICAL RESEARCH METHODS
Journal of Fluorescence Pub Date : 2025-06-01 Epub Date: 2024-07-11 DOI:10.1007/s10895-024-03826-2
Duraisamy Udhayakumari, Subramaniyan Ramasundaram, Peter Jerome, Tae Hwan Oh
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引用次数: 0

摘要

这篇综述深入探讨了为生物成像应用定制的基于小分子的荧光化学传感器,展示了它们以卓越的灵敏度和选择性将生物过程可视化的独特能力。它探讨了这一领域的最新进展、方法和应用,重点关注蒽、苯并噻唑、萘、喹啉和希夫碱的各种设计。文章强调了结构调整和分子工程策略对提高传感器性能的作用,包括提高灵敏度、选择性和生物相容性。此外,这篇综述还为这些化学传感器的持续开发和利用提供了宝贵的见解,解决了当前面临的挑战,并为这一快速发展的领域指明了未来的方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A Review on Small Molecule Based Fluorescence Chemosensors for Bioimaging Applications.

A Review on Small Molecule Based Fluorescence Chemosensors for Bioimaging Applications.

This review provides a thorough examination of small molecule-based fluorescence chemosensors tailored for bioimaging applications, showcasing their unique ability to visualize biological processes with exceptional sensitivity and selectivity. It explores recent advancements, methodologies, and applications in this domain, focusing on various designs rooted in anthracene, benzothiazole, naphthalene, quinoline, and Schiff base. Structural modifications and molecular engineering strategies are emphasized for enhancing sensor performance, including heightened sensitivity, selectivity, and biocompatibility. Additionally, the review offers valuable insights into the ongoing development and utilization of these chemosensors, addressing current challenges and charting future directions in this rapidly evolving field.

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来源期刊
Journal of Fluorescence
Journal of Fluorescence 化学-分析化学
CiteScore
4.60
自引率
7.40%
发文量
203
审稿时长
5.4 months
期刊介绍: Journal of Fluorescence is an international forum for the publication of peer-reviewed original articles that advance the practice of this established spectroscopic technique. Topics covered include advances in theory/and or data analysis, studies of the photophysics of aromatic molecules, solvent, and environmental effects, development of stationary or time-resolved measurements, advances in fluorescence microscopy, imaging, photobleaching/recovery measurements, and/or phosphorescence for studies of cell biology, chemical biology and the advanced uses of fluorescence in flow cytometry/analysis, immunology, high throughput screening/drug discovery, DNA sequencing/arrays, genomics and proteomics. Typical applications might include studies of macromolecular dynamics and conformation, intracellular chemistry, and gene expression. The journal also publishes papers that describe the synthesis and characterization of new fluorophores, particularly those displaying unique sensitivities and/or optical properties. In addition to original articles, the Journal also publishes reviews, rapid communications, short communications, letters to the editor, topical news articles, and technical and design notes.
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