远视性异向性弱视儿童感光器外节层增厚。

IF 2.1 4区 医学 Q2 OPHTHALMOLOGY
Indian Journal of Ophthalmology Pub Date : 2024-12-01 Epub Date: 2024-07-11 DOI:10.4103/IJO.IJO_3068_23
Wenli Zhang, Fan Yang, Shirong Chen, Tingkun Shi
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引用次数: 0

摘要

目的:使用扫源光学相干断层扫描(SS-OCT)定量研究远视性异向性弱视儿童视网膜外层的反射率和结构:本研究共纳入 78 名弱视患者和 64 名视力正常的年龄匹配儿童。所有参与者都接受了 SS-OCT 和详细的眼科检查。在三个选定位置测量视网膜外层的反射率:眼窝下、眼窝鼻侧 1 毫米和眼窝颞侧 1 毫米。视网膜外层除以核层(ONL)计算出反射率比率,以进行归一化处理。同时还测量了感光体外节层的厚度。弱视对照组与正常对照组的结果进行了比较。通过广义估计方程调整了年龄、性别和轴长对结果的可能影响:结果:弱视眼的感光体外节层厚度在所有三个区域都明显大于正常对照组(在眼窝处为 18.41 ± 1.83 vs. 16.84 ± 1.39,P < 0.001;在眼窝鼻侧 1 mm 处为 14.78 ± 1.34 vs. 14.19 ± 1.40,P = 0.030;在眼窝颞侧 1 mm 处为 14.92 ± 1.48 vs. 14.41 ± 1.32,P = 0.049)。只有在距离眼窝鼻侧 1 毫米处,外段/ONL 的反射率比值较高(2.94 ± 0.61 vs. 2.70 ± 0.42,P = 0.02)。眼窝下 OS 厚度与脉络膜厚度呈正相关(r = 0.248,P = 0.018),但与球面等值、年龄、轴向长度或 logMAR 视力无关:结论:SS-OCT 图像的定量测量显示,弱视儿童双眼的感光体外节均大于正常对照眼。较厚的视网膜厚度与弱视有一定关系,这可能是诊断弱视的一个新的有用参数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Thickened photoreceptor outer segment layer in children with hyperopic anisometropic amblyopia.

Purpose: To quantitatively investigate the reflectivity and structure of the outer retinal layers in children with hyperopic anisometropic amblyopia by using swept-source optical coherence tomography (SS-OCT).

Methods: Seventy-eight patients with amblyopia and 64 age-matched children with normal vision were included in this study. All participants underwent SS-OCT and detailed ophthalmic examinations. Longitudinal reflectance profile measurements were measured using Image J. The reflectivity of outer retinal layers was measured at the three selected positions: subfovea, 1 mm nasal to the fovea, and 1 mm temporal to the fovea. The reflectivity ratios were calculated by outer retinal layers divided by the nuclear layer (ONL) for normalization. Photoreceptor outer segment layer thickness was also measured. The results were compared between the amblyopia and normal controls. The possible effects of age, sex, and axial length on results were adjusted by generalized estimating equations.

Results: Photoreceptor outer segment layer thickness was significantly greater in amblyopic eyes than in normal control eyes at all three regions (18.41 ± 1.83 vs. 16.84 ± 1.39, P < 0.001 at the fovea; 14.78 ± 1.34 vs. 14.19 ± 1.40, P = 0.030 at 1 mm nasal to the foveal; 14.92 ± 1.48 vs. 14.41 ± 1.32, P = 0.049 at 1 mm temporal to the fovea). The reflectivity ratio of outer segment/ONL was higher only at 1 mm nasal to the fovea (2.94 ± 0.61 vs. 2.70 ± 0.42, P = 0.02). Subfoveal OS thickness was positively correlated with choroidal thickness (r = 0.248, P = 0.018) but was not correlated with spherical equivalent, age, axial length, or logMAR visual acuity.

Conclusion: Quantitative measurement of SS-OCT images revealed greater photoreceptor outer segments in both eyes of children with amblyopia than in normal control eyes. A thicker OS thickness is somehow related to amblyopia, and this may be a new useful diagnostic parameter for amblyopia.

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来源期刊
CiteScore
3.80
自引率
19.40%
发文量
1963
审稿时长
38 weeks
期刊介绍: Indian Journal of Ophthalmology covers clinical, experimental, basic science research and translational research studies related to medical, ethical and social issues in field of ophthalmology and vision science. Articles with clinical interest and implications will be given preference.
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