BDNF Val66Met 多态性是精神病患者体重的潜在标记。

IF 3.1 Q2 NEUROSCIENCES
AIMS Neuroscience Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI:10.3934/Neuroscience.2024012
Yinghua Zhang, Xinyue Wei, Wenhao Zhang, Feng Jin, Wenbo Cao, Mingjin Yue, Saijun Mo
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引用次数: 0

摘要

脑源性神经营养因子(BDNF)是大脑中最主要的神经营养因子,对神经元生长、突触发育、神经元修复和海马神经可塑性不可或缺。在其基因变异中,BDNF Val66Met 多态性在人群中广泛存在,并与多种病症的发生和加重有关,包括肥胖和糖尿病等代谢性疾病、心血管疾病、癌症和一系列精神疾病。精神疾病是影响情绪、认知和行为的一大类精神健康问题。尽管研究和治疗取得了进展,但挑战依然存在,这阻碍了我们对这些多方面疾病的理解和有效干预。实现并保持稳定的体重对于整体健康和幸福感至关重要,而精神疾病与体重之间的关系显然是错综复杂且相互影响的。体重增加和减轻都与不同的心理健康挑战有关,因此,厘清这种关系对于制定整体治疗策略至关重要。BDNF Val66Met 多态性与精神病患者体重波动的关系引起了人们的关注。本综述研究了 BDNF Val66Met 多态性对精神病患者体重的影响及其潜在机制。它认为该多态性是一种潜在的生物标志物,为改进精神疾病的监测和治疗方法提供了前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The BDNF Val66Met polymorphism serves as a potential marker of body weight in patients with psychiatric disorders.

Brain-derived neurotrophic factor (BDNF) is a predominant neurotrophic factor in the brain, indispensable for neuronal growth, synaptic development, neuronal repair, and hippocampal neuroplasticity. Among its genetic variants, the BDNF Val66Met polymorphism is widespread in the population and has been associated with the onset and aggravation of diverse pathologies, including metabolic conditions like obesity and diabetes, cardiovascular ailments, cancer, and an array of psychiatric disorders. Psychiatric disorders constitute a broad category of mental health issues that influence mood, cognition, and behavior. Despite advances in research and treatment, challenges persist that hinder our understanding and effective intervention of these multifaceted conditions. Achieving and maintaining stable body weight is pivotal for overall health and well-being, and the relationship between psychiatric conditions and body weight is notably intricate and reciprocal. Both weight gain and loss have been linked to varying mental health challenges, making the disentanglement of this relationship critical for crafting holistic treatment strategies. The BDNF Val66Met polymorphism's connection to weight fluctuation in psychiatric patients has garnered attention. This review investigated the effects and underlying mechanisms by which the BDNF Val66Met polymorphism moderates body weight among individuals with psychiatric disorders. It posits the polymorphism as a potential biomarker, offering prospects for improved monitoring and therapeutic approaches for mental illnesses.

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来源期刊
AIMS Neuroscience
AIMS Neuroscience NEUROSCIENCES-
CiteScore
4.20
自引率
0.00%
发文量
26
审稿时长
8 weeks
期刊介绍: AIMS Neuroscience is an international Open Access journal devoted to publishing peer-reviewed, high quality, original papers from all areas in the field of neuroscience. The primary focus is to provide a forum in which to expedite the speed with which theoretical neuroscience progresses toward generating testable hypotheses. In the presence of current and developing technology that offers unprecedented access to functions of the nervous system at all levels, the journal is designed to serve the role of providing the widest variety of the best theoretical views leading to suggested studies. Single blind peer review is provided for all articles and commentaries.
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